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Direct Acting Vasodilator
Aka: Direct Acting Vasodilator, Hydralazine, Apresoline, Diazoxide, Hyperstat, BiDil- See Also
- Direct Acting Vasodilators IV
- Hydralazine (Apresoline)
- Dose: 10-40 mg IV/IM q4-6h
- Hydralazine with Isosorbide Dinitrate 37.5/20 (BiDil)
- Dose: 1-2 tablets PO tid
- For Class III CHF patients (esp. African American)
- Very expensive: $400/month
- Generic Drugs separately are $60/month
- Diazoxide (Hyperstat)
- Dose: 1-3 mg/kg up to 150 mg IV q5-15 min
- NitroprussideSodium (Nipride)
- Minoxidil (Loniten)
- Hydralazine (Apresoline)
Medication Costs | ||
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Hydralazine (on 6/18/2017 at Walmart.com) | ||
Hydralazine 10mg | #30 tablets for $4.00 | $0.13 each |
Hydralazine 10mg | #90 tablets for $10.00 | $0.11 each |
Hydralazine 25mg | #30 tablets for $4.00 | $0.13 each |
Hydralazine 25mg | #90 tablets for $10.00 | $0.11 each |
hydralazine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
HYDRALAZINE 10 MG TABLET | Generic | $0.04 each |
HYDRALAZINE 100 MG TABLET | Generic | $0.10 each |
HYDRALAZINE 25 MG TABLET | Generic | $0.05 each |
HYDRALAZINE 50 MG TABLET | Generic | $0.06 each |
bidil (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
BIDIL TABLET | $2.96 each | |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Diazoxide (C0012022) |
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Definition (NCI) | A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells. |
Definition (CSP) | peripheral vasodilator that reduces blood pressure; diazoxide also has antidiuretic and hypoglycemic effects. |
Definition (MSH) | A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. |
Definition (PDQ) | A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39290&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39290&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C428" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D003981 |
SnomedCT | 318642007, 325291008, 387328001, 58905004 |
LNC | LP14713-9, MTHU001807 |
English | Diazoxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide, 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, diazoxide, Diazoxide [cardiovascular use], Diazoxide [endocrine use], diazoxide (medication), Diazoxide [Chemical/Ingredient], diazoxides, Diazoxide [cardiovascular use] (product), Diazoxide [endocrine use] (product), Diazoxide (product), Diazoxide (substance), Diazoxide [cardiovascular use] (substance), Diazoxide [endocrine use] (substance), DIAZOXIDE |
Swedish | Diazoxid |
Czech | diazoxid |
Finnish | Diatsoksidi |
Russian | DIAZOKSID, ДИАЗОКСИД |
Japanese | ダイアゾキサイド, ジアゾキシド |
Croatian | DIAZOKSID |
Polish | Diazoksyd |
Spanish | diazóxido (uso cardiovascular), diazóxido [uso endocrino], diazóxido (uso cardiovascular) (producto), diazóxido [uso endocrino] (producto), diazóxido (producto), diazóxido (sustancia), diazóxido, Diazóxido |
French | Diazoxide |
German | Diazoxid |
Italian | Diazossido |
Portuguese | Diazóxido |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Hydralazine (C0020223) |
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Definition (NCI) | A phthalazine derivative with antihypertensive effects. Hydralazine exerts its vasodilatory effects through modification of the contractile state of arterial vascular smooth muscle by altering intracellular calcium release, and interfering with smooth muscle cell calcium influx. This agent also causes inhibition of phosphorylation of myosin protein or chelation of trace metals required for smooth muscle contraction, thereby resulting in an increase in heart rate, stroke volume and cardiac output. |
Definition (MSH) | A direct-acting vasodilator that is used as an antihypertensive agent. |
Definition (CSP) | direct-acting vasodilator that is used as an antihypertensive. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D006830 |
SnomedCT | 22696000, 387125005 |
LNC | LP15169-3, MTHU002558 |
English | Apressin, Hydralazine, Hydrallazin, Hydrazinophthalazine, 1(2H)-Phthalazinone, hydrazone, apressin, 1(2H)-Phthalazinone Hydrazone, Hydralazine [Chemical/Ingredient], HYDRALAZINE, hydrALAZINE, hydralazine (medication), hydralazine, Apressinum, Hydralazine (product), Hydralazine (substance) |
Swedish | Hydralazin |
Czech | hydralazin |
Finnish | Hydralatsiini |
Russian | APRESSIN, GIDRALAZIN, АПРЕССИН, ГИДРАЛАЗИН |
Italian | Apressina, Idrallazina, Idrazinoftalazina, Idralazina |
Spanish | Hidralazina, Hidralacina, hidralazina (producto), hidralazina (sustancia), hidralazina |
Polish | Hydralazyna |
Japanese | ヒドララジン, 塩酸ヒドララジン |
French | Hydralazine |
German | Hydralazin, Hydrallazin |
Portuguese | Hidralazina |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Apresoline (C0699178) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D006830 |
English | Apresoline, apresoline, Apressoline |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Hyperstat (C0699324) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D003981 |
English | Hyperstat |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Bidil (C0968130) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C431665 |
English | Bidil, BiDil |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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