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Antiarrhythmic

Aka: Antiarrhythmic, Vaughn Williams Classification
  1. Preparations: Class I - Sodium Channel Blockade
    1. Class Ia: Lengthens action potential duration
      1. Quinidine
      2. Procainamide (Pronestyl)
      3. Disopyramide (Norpace)
      4. Amiodarone (also Class II, III, IV)
      5. Several non-classic Antiarrhythmics have Class Ia activity (e.g. Imipramine, a Tricyclic Antidepressant)
    2. Class Ib: Shortens action potential duration
      1. Lidocaine (Xylocaine)
      2. Tocainide (Tonocard)
      3. Mexiletine (Mexitil)
      4. Phenytoin (Dilantin)
    3. Class Ic: Slows conduction
      1. Flecainide (Tambocor)
      2. Encainide (Enkaid)
      3. Propafenone (Rythmol)
  2. Preparations: Class II - Beta Blocker
    1. Propranolol
    2. Metoprolol
    3. Atenolol
    4. Carvedilol (Coreg)
    5. Esmolol (Brevibloc)
    6. Sotalol (also Class III)
    7. Amiodarone (also Class Ia, III, IV)
  3. Preparations: Class III - Blocks potassiun channels, prolongs repolarization
    1. Bretylium (Bretylol)
    2. Sotalol
    3. Amiodarone (also Class Ia, II, IV)
    4. Dofetilide (Tikosyn)
    5. Dronedarone (Multaq)
  4. Preparations: Class IV - Calcium Channel Blocker, blocks slow calcium channel
    1. Verapamil (Calan)
    2. Diltiazem (Cardizem)
    3. Nifedipine
    4. Amiodarone (also Class Ia, II, III)
  5. References
    1. Helton (2015) Am Fam Physician 92(9): 793-800 [PubMed]

Anti-Arrhythmia Agents (C0003195)

Definition (NCI) Agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.(CRISP)
Definition (MSH) Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Definition (CSP) group of agents used for the treatment or prevention of cardiac arrhythmias; they may effect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers.
Concepts Pharmacologic Substance (T121)
MSH D000889
SnomedCT 67507000, 372813008
English Agents, Anti-Arrhythmia, Anti Arrhythmia Agents, antiarrhythmic agent, Agents, Antiarrhythmia, Anti Arrhythmia Drugs, Anti Arrhythmics, Anti-Arrhythmia Drugs, Anti-Arrhythmics, Antiarrhythmia Agents, Antiarrhythmia Drugs, Antiarrhythmic Drugs, Drugs, Anti-Arrhythmia, Drugs, Antiarrhythmia, Drugs, Antiarrhythmic, Antiarrhythmic Agent, ANTIARRHYTHMIA AGENTS, ANTIARRHYTHMICS, antiarrhythmic agents (medication), anti-arrhythimia agents, antiarrhythmic agents, Cardiac Depressant, Antiarrhythmic, Anti-arrhythmic Agent, [CV300] ANTIARRHYTHMICS, Anti-arrhythmic, Anti-arrhythmic Agent [TC], agents antiarrhythmic, antiarrhythmia drugs, antiarrhythmic drugs, anti arrhythmia drugs, anti arrhythmic, antiarrhythmic, anti arrhythmics, anti-arrhythmia drugs, antiarrhythmia agents, anti-arrhythmics, antiarrhythmic drug, antiarrhythmics, Anti-Arrhythmia Agents, Antiarrhythmic drug, Antiarrhythmic agent (substance), Antiarrhythmic agent, Antiarrhythmic drug (product), Antiarrhythmic drug, NOS, Antiarrhythmic drug (substance), antiarrhythmia, Antiarrhythmics
French Médicaments antiarythmiques, Anti-arythmiques, Agents antiarythmiques, Antiarythmisants, Antiarythmiques
Swedish Antiarytmika
Czech antiarytmika
Finnish Rytmihäiriölääkkeet
Italian Farmaci antiaritmia, Farmaci antiaritmici, Antiaritmici
Russian PROTIVOARITMICHESKIE SREDSTVA, MIOKARDIAL'NYE DEPRESSANTY, KARDIAL'NYE DEPRESSANTY, ANTIARITMICHESKIE SREDSTVA, ANTIFIBRILLIATORNYE SREDSTVA, АНТИАРИТМИЧЕСКИЕ СРЕДСТВА, АНТИФИБРИЛЛЯТОРНЫЕ СРЕДСТВА, КАРДИАЛЬНЫЕ ДЕПРЕССАНТЫ, МИОКАРДИАЛЬНЫЕ ДЕПРЕССАНТЫ, ПРОТИВОАРИТМИЧЕСКИЕ СРЕДСТВА
Japanese 抗不整脈薬, 不整脈治療薬, 心筋抑制薬, 心抑制薬, 抗不整脈剤, 抗心臓細動薬
Croatian ANTIARITMIJSKI LIJEKOVI
Polish Leki przeciwarytmiczne, Depresanty mięśnia sercowego, Antyarytmiki, Leki antyarytmiczne
Spanish Antiarrítmicos, Agentes Antiarrítmicos, agente antiarrítmico (sustancia), agente antiarrítmico, antiarrítmicos, antiarrítmico, droga antiarrítmica (producto), droga antiarrítmica (sustancia), droga antiarrítmica, fármaco antiarrítmico (producto), fármaco antiarrítmico
Portuguese Agentes Antiarrítmicos, Antiarrítmicos
German Antiarrhythmika
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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