//fpnotebook.com/
Acetazolamide
Aka: Acetazolamide, Diamox- Mechanism
- Carbonic Anhydrase Inhibitor
- Indications
- High Altitude Sickness treatment and prevention
- Pseudotumor Cerebri
- Contraindications
- Dosing
- High Altitude Sickness
- Prevention: 125 mg PO bid
- Start 24 hours before ascent
- Continue for 72 hours or until acclimitization to highest sleeping altitude
- Insomnia at altitude: 125 mg PO qhs
- Treatment: 250 mg orally twice daily (up to 400 mg twice daily has been sed)
- Prevention: 125 mg PO bid
- Pseudotumor Cerebri
- Dose range: 125-250 mg PO qd-tid
- High Altitude Sickness
- Adverse Effects
- Peripheral Paresthesias (common)
- Polyuria
Medication Costs | ||
---|---|---|
acetazolamide (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
ACETAZOLAMIDE 125 MG TABLET | Generic | $1.55 each |
ACETAZOLAMIDE 250 MG TABLET | Generic | $1.82 each |
ACETAZOLAMIDE ER 500 MG CAP | Generic | $1.69 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Acetazolamide (C0000981) |
|
---|---|
Definition (NCI) | A sulfonamide derivative with diuretic, antiglaucoma, and anticonvulsant properties. Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme found in cells in the proximal tube of the kidney, the eye, and glial cells. Inhibition of this enzyme in the kidney prevents excretion of hydrogen, leading to increased bicarbonate and cation excretion and increased urinary volume, which results in an alkaline diuresis. Acetazolamide reduces the concentration of bicarbonate, resulting in a decreased synthesis of aqueous humor in the eye, thereby lowering intraocular pressure. Although its mechanism of action is unknown, acetazolamide has anti-convulsant properties resulting from indirect effects secondary to metabolic acidosis or direct effects on neuronal transmission. Acetazolamide also produces respiratory stimulant effects in response to changes to both carbon dioxide and oxygen tension levels within the lungs. |
Definition (MSH) | One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337) |
Definition (CSP) | carbonic anhydrase inhibitor that is sometimes effective against seizures. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D000086 |
SnomedCT | 330592008, 391705005, 322853009, 372709008, 33664007 |
LNC | LP16018-1, MTHU005569 |
English | Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-, Acetazolamide [epilepsy], Acetazolamide [glaucoma], N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide, acetazolamide, acetazolamide (medication), ACETAZOLAMIDE, Acetazolamide [Chemical/Ingredient], acetazolamides, acetaZOLAMIDE, Acetazolamide [glaucoma] (product), Acetazolamide - chemical, Acetazolamide - chemical (substance), Acetazolamide [epilepsy] (product), N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide, Acetazolamide (product), Acetazolamide (substance), Acetazolamide [epilepsy] (substance), Acetazolamide [glaucoma] (substance), Acetazolamide, AcetaZOLAMIDE |
Swedish | Acetazolamid |
Czech | acetazolamid |
Finnish | Asetatsoliamidi |
Russian | DIAKARB, ATSETAZOLAMID, АЦЕТАЗОЛАМИД, ДИАКАРБ |
Croatian | ACETAZOLAMID |
Polish | Diamoks, Acetazolamid |
Japanese | アセタゾールアミド, アセタゾラミド |
Spanish | acetazolamida - sustancia química, acetazolamida - sustancia química (sustancia), acetazolamida (antiglaucomatoso) (producto), acetazolamida (antiglaucomatoso), acetazolamida (antiepiléptico), acetazolamida (antiepiléptico) (producto), acetazolamida (glaucoma) (producto), acetazolamida (glaucoma), acetazolamida (producto), acetazolamida (sustancia), acetazolamida [epilepsia] (producto), acetazolamida [epilepsia], acetazolamida, Acetazolamida |
French | Acétazolamide |
German | Acetazolamid, Azetazolamid |
Italian | Acetazolamide |
Portuguese | Acetazolamida |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Diamox (C0591362) |
|
---|---|
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D000086 |
English | diamox, Cyanamid Brand of Acetazolamide Preparation, Lederle Brand of Acetazolamide Preparation, Storz Brand of Acetazolamide Preparation, Whelehan Brand of Acetazolamide Preparation, Wyeth Brand of Acetazolamide Preparation, Diamox, Théraplix Brand of Acetazolamide Preparation |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.
If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.
Please Contact Me as you run across problems with any of these versions on the website.