II. Pharmacology
- Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
- Sulfonamide Allergy does not cross react with sulfur, sulfate, Sulfites
III. Preparations: Sulfonylarylamines (Sulfa agents)
-
General
- Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
- Sulfa Antibiotics
- Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
- Sulfadiazine
- Sulfacetamide
- Sulfa Antiinflammatories
- Protease Inhibitors (HIV Infection)
IV. Preparations: Non-Sulfonylarylamines
-
General
- Similar structure to Sulfonylarylamines , but hypersensitivity cross-reactivity is uncommon
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
-
Diuretics
- All Thiazide Diuretics
- Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
- Anti-hyperglycemics (Diabetes Mellitus)
- Sulfonylureas (e.g. Glipizide)
- Analgesics
V. Preparations: Sulfonamide Moieties
-
General
- Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
- Neurologic agents
- Sumatriptan (Imitrex)
- Topiramate (Topamax)
- Zonisamide (Zonagran)
-
Protease Inhibitor (Hepatitis C Infection)
- Simeprevir (Olysio)
VI. References
- (2014) Presc Lett 21(2): 10-11
- Ghimire (2013) J Clin Pharm Ther 38: 196–202 [PubMed]
- Wulf (2013) Am J Health Syst Pharm 70:1483-94 [PubMed]
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| Concepts | Disease or Syndrome (T047) |
| SnomedCT | 91939003 |
| English | SULFA ALLERGY, allergy sulfas, allergy to sulfa drugs, allergies drugs sulpha, allergies drug sulfa, allergy sulfa, sulfa drugs allergy, allergies sulfonamide, sulfa allergy, allergies sulfa, sulfonamide allergy, allergy drug sulfa, allergy drug sulpha, Sulfonamide allergy, Sulphonamide allergy, Allergy to sulfa drugs, Allergy to sulfonamides, Allergy to sulfonamides (disorder), Allergy to sulpha drugs, Allergy to sulphonamides |
| Dutch | allergie voor sulfonamide |
| French | Allergie aux sulfonamides |
| German | Sulfonamidallergie |
| Italian | Allergia alla sulfonamide |
| Portuguese | Alergia a sulfonamida |
| Spanish | Alergia a sulfonamidas, alergia a las sulfamidas, alergia a las sulfonamidas (trastorno), alergia a las sulfonamidas |
| Japanese | スルホンアミドアレルギー, ｽﾙﾎﾝｱﾐﾄﾞｱﾚﾙｷﾞｰ |
| Czech | Alergie na sulfonamidy |
| Hungarian | Szulfonamid allergia |
