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Ontology:
Cefuroxime
(C0007562)
Definition (NCI)
|
A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
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Definition (MSH)
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Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
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Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
MSH |
D002444
|
SnomedCT |
372833007, 73986003 |
LNC |
LP32648-5, MTHU027952 |
English |
Cefuroxime, Cephuroxime, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-, cefuroxime (medication), Cefuroxime [Chemical/Ingredient], CEFUROXIME, cephuroxime, cefuroxime, Cefuroxime (product), Cefuroxime (substance) |
Swedish |
Cefuroxim
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Czech |
cefuroxim
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Finnish |
Kefuroksiimi
|
Russian |
TSEFUROKSIM, ЦЕФУРОКСИМ |
Japanese |
セフロキシム
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Croatian |
CEFUROKSIM
|
Polish |
Cefuroksym
|
Spanish |
cefuroxima (producto), cefuroxima (sustancia), cefuroxima, Cefuroxima |
French |
Céfuroxime
|
German |
Cefuroxim
|
Italian |
Cefuroxima
|
Portuguese |
Cefuroxima
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Ontology:
cefprozil
(C0053882)
Definition (NCI)
|
A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefprozil's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefprozil inhibits bacterial septum and cell wall synthesis formation.
|
Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
MSH |
C052018
|
SnomedCT |
387538005, 96054007 |
LNC |
LP15219-6, MTHU001907 |
English |
cefprozil, CEFPROZIL, cefprozil (medication), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-, cefprozil [Chemical/Ingredient], Cefprozil, Cefprozil (product), Cefprozil (substance) |
Spanish |
cefprozilo (producto), cefprozilo, cefprozilo (sustancia), cefprozil, cefprozil (producto), cefprozil (sustancia) |
Ontology:
loracarbef
(C0065295)
Definition (NCI)
|
A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents.
|
Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
MSH |
C054920
|
SnomedCT |
96061006, 370362008 |
LNC |
LP15927-4, MTHU008099 |
English |
1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6alpha,7beta(R*)))-, loracarbef, (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate, loracarbef (medication), loracarbef [Chemical/Ingredient], Carbacefaclor, Loracarbef, Loracarbef (substance), Loracarbef product (product), Loracarbef product, LORACARBEF |
Spanish |
loracarbef, producto con loracarbef (producto), loracarbef (producto), producto con loracarbef, carbacefaclor (sustancia), carbacefaclor |
Ontology:
Ceftin
(C0719197)
Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
MSH |
C040738
|
English |
Ceftin, ceftin |
Ontology:
Lorabid
(C0721422)
Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
MSH |
C054920
|
English |
lorabid, Lilly Brand of Loracarbef Monohydrate, Monarch Brand of Loracarbef Monohydrate, Lorabid |
Ontology:
Cefzil
(C0728743)
Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
MSH |
C052018
|
English |
Cefzil, cefzil, Bristol-Myers Squibb brand of cefprozil |