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Ontology:
Ivermectin
(C0022322)
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Definition (NCI)
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A macrocyclic lactone derived from Streptomyces avermitilis with antiparasitic activity. Ivermectin exerts its anthelmintic effect via activating glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells. Distinct from the channel opening induced by endogenous glutamate transmitter, ivermectin-activated channels open very slowly but essentially irreversibly. As a result, neurons or muscle cells remain at either hyperpolarisation or depolarization state, thereby resulting in paralysis and death of the parasites. Ivermectin does not readily pass the mammal blood-brain barrier to the central nervous system where glutamate-gated chloride channels locate, hence the hosts are relatively resistant to the effects of this agent.
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Definition (MSH)
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A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D007559
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| SnomedCT |
387559003, 96138006 |
| English |
Ivermectin, ivermectin, ivermectin (medication), IVERMECTIN, Ivermectin [Chemical/Ingredient], Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-, Ivermectin (product), Ivermectin (substance) |
| Swedish |
Ivermektin
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| Czech |
ivermektin
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| Finnish |
Ivermektiini
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| Russian |
IVERMEKTIN, ИВЕРМЕКТИН |
| Japanese |
イベルメクチン
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| Polish |
Iwermektyna, Ivermectin |
| Spanish |
ivermectina (producto), ivermectina (sustancia), ivermectina, Ivermectina |
| French |
Ivermectine
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| German |
Ivermectin
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| Italian |
Ivermectina
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| Portuguese |
Ivermectina
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Ontology:
Stromectol
(C0723477)
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Definition (MSH)
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Oral preparation of ivermectin.
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| Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
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| MSH |
D007559
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| English |
Stromectol, Ivermectin Merck Brand, Merck Brand of Ivermectin |
Ontology:
Mectizan
(C0751253)
| Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
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| MSH |
D007559
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| English |
Mectizan
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