Fourth Generation Fluoroquinolone

Aka: Fourth Generation Fluoroquinolone, Fourth Generation Quinolone, Trovafloxacin, Trovan

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II. Preparations

  1. See Delafloxacin (Baxdela)
  2. Trovafloxacin (Trovan)

III. Pharmacology: Activity Spectrum

  1. Gram Negative Bacteria (Enterobacteriaceae)
  2. Atypical Bacteria
  3. Staphylococcus aureus (Methicillin susceptible)
  4. Streptococci
    1. Improved coverage over Third Generation Quinolones
  5. Anaerobic Bacteria
    1. Not covered by Third Generation Quinolones
  6. Pseudomonas aeruginosa coverage varies
    1. Delafloxacin (Baxdela) has good Pseudomonas coverage
    2. Trovafloxacin (Trovan) has minimal Pseudomonas coverage

IV. Indications

  1. Intra-abdominal infections
  2. Avoid Trovafloxacin in UTI (low urine concentrations)

V. References

  1. King (2000) Am Fam Physician 61(9):2741-8 [PubMed]
  2. O'Donnell (2000) Infect Dis Clin North Am 14(2):489-513 [PubMed]
  3. Oliphant (2002) Am Fam Physician 65(3):455-64 [PubMed]
  4. Owens (2000) Med Clin North Am 84(6):1447-69 [PubMed]

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Related Studies

Ontology: trovafloxacin (C0379881)

Concepts Organic Chemical (T109) , Antibiotic (T195)
MSH C080163
SnomedCT 96092008, 371322001
LNC LP17281-4, MTHU011341
English trovafloxacin, TROVAFLOXACIN, trovafloxacin (medication), trovafloxacin [Chemical/Ingredient], 7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)- 1-(2,4-difluorophenyl)- 6-fluoro-4-oxo-[1,8] naphthyridine-3-carboxylic acid, Trovafloxacin, Trovafloxacin (substance), Trovafloxacin product (product), Trovafloxacin product
Spanish producto con trovafloxacina (producto), producto con trovafloxacina, trovafloxacina, trovafloxacino (producto), trovafloxacino (sustancia), trovafloxacino, trovafloxacina (producto), trovafloxacina (sustancia)
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Trovan (C0723938)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C106856
English Trovan, trovan, Pfizer brand of alatrofloxacin mesylate
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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