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Ontology:
Amantadine
(C0002403)
Definition (NCI)
|
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.
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Definition (MSH)
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An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
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Definition (CSP)
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antiviral that is used in the prophylactic or symptomatic treatment of influenza A; it is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D000547
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SnomedCT |
372763006, 51361008 |
LNC |
LP14353-4, MTHU006774 |
English |
1-Aminoadamantane, Adamantylamine, Amantadine, 1 Aminoadamantane, Tricyclo(3.3.1.13,7)decan-1-amine, Amantadine [Chemical/Ingredient], amatadine, AMANTADINE, amantadine, Amantadine (product), Amantadine (substance), Amatadine |
Swedish |
Amantadin
|
Czech |
amantadin
|
Finnish |
Amantadiini
|
Italian |
1-Aminoadamantano, Adamantilamina, Amantadina |
Russian |
AMANTADIN, АМАНТАДИН |
Japanese |
アマンタジン
|
Croatian |
AMANTADIN
|
Polish |
Symmetrel, Amantadyna |
Spanish |
amantadina (producto), amantadina (sustancia), amantadina, Amantadina |
French |
Amantadine
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German |
Amantadin
|
Portuguese |
Amantadina
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Ontology:
Symmetrel
(C0026055)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D000547
|
English |
symmetrel, Ciba Geigy Brand of Amantadine Hydrochloride, Ciba-Geigy Brand of Amantadine Hydrochloride, Du Pont Brand of Amantadine Hydrochloride, Endantadine, Endo Brand of Amantadine Hydrochloride, Mantadix, Novartis Brand of Amantadine Hydrochloride, Alliance Brand of Amantadine Hydrochloride, Symmetrel |
Ontology:
Rimantadine
(C0035629)
Definition (NCI)
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A cyclic amine and alpha-methyl derivative of amantadine with antiviral activity. Although the exact mechanism of action of rimantadine is not understood, this agent appears to exert its antiviral effect against influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells.
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Definition (MSH)
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An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D012299
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SnomedCT |
108712009, 372532009 |
English |
Remantadine, Riamantadine, Rimantadine, Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, Rimantadine [Chemical/Ingredient], remantadine, RIMANTADINE, 1-(1-Adamantyl)ethylamin, Tricyclo(3.3.1.1(sup 3,7))decane-1-methanamine, alpha-methyl-, HSDB 7438, alpha-Methyl-1-adamantanemethylamine, rimantadine, Rimantadine (product), Rimantadine (substance) |
Swedish |
Rimantadin
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Czech |
rimantadin
|
Finnish |
Rimantadiini
|
Russian |
REMANTADIN, RIMANTADIN, РЕМАНТАДИН, РИМАНТАДИН |
Japanese |
リマンタジン, レマンタジン |
Polish |
Rymantadyna
|
Spanish |
rimantadina (producto), rimantadina (sustancia), rimantadina, Remantadina, Rimantadina |
French |
Rimantadine
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German |
Remantadin, Rimantadin |
Italian |
Rimantadina
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Portuguese |
Remantadina, Rimantadina |
Ontology:
Flumadine
(C0733408)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D012299
|
English |
Flumadine, Forest Brand of Rimantadine Hydrochloride |