II. Physiology

  1. Pentamer (5 Antibody molecules) when secretory Ig with Molecular weight 900,000 dalton
  2. Responsible for early, primary Antibody response

III. Lab: Normal

  1. Range: 45-150 mg/dl
  2. Varies by age

IV. Causes: Increased

  1. Liver disease
    1. Primary biliary Cirrhosis
    2. Early hepatitis
  2. Waldenstrom's Macroglobulinemia
  3. Infection
    1. Brucellosis
    2. Malaria
    3. Trypanosomiasis
    4. Toxoplasmosis

V. Causes: Decreased

  1. Hypo-IgM
  2. Protein-losing Enteropathy

VI. References

  1. Bakerman (1984) ABCs of Lab Data, p. 252-3

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Ontology: Immunoglobulin M (C0020861)

Definition (NCI) The major immunoglobulin secreted during a primary immune response. IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers.
Definition (CSP) pentameric immunoglobulin largely confined to the intravascular pool and the predominant early antibody frequently seen in the immune response to antigenically complex infectious organisms.
Definition (MSH) A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D007075
SnomedCT 165941002, 143329009, 74889000
LNC LP14674-3, MTHU004563
English 19S Gamma Globulin, Gamma Globulin, 19S, IgM, Immunoglobulin M, Immunoglobulin M [Chemical/Ingredient], immunoglobulin m (IgM), immunoglobulin m, immune globulin,mu (IgM), Immunoglobulin M (procedure), Immunoglobulin IgM, Immunoglobulin IgM (substance), Immunoglobulin M (substance), immunoglobulin M, IgM - Immunoglobulin M, Immunoglobulin IgM, NOS
Swedish Immunglobulin M
Czech IgM, imunoglobulin M
Finnish Immunoglobuliini M
Italian Gamma globulina 19S, IgM, Immunoglobulina M
German GAMMAGLOBULIN 19S, 19S-Gammaglobulin, IgM, Immunglobulin M
French Gamma-globuline 19S, Globuline gamma 19S, Gammaglobuline 19S, IgM, Immunoglobuline M
Polish IgM, Gamma globulina 19S, Immunoglobulina M
Japanese 免疫グロブリンM, 19Sガンマグロブリン
Spanish Inmunoglobulinas M, inmunoglobulina IgM (sustancia), inmunoglobulina M (sustancia), inmunoglobulina IgM, inmunoglobulina M, IgM, Inmunoglobulina M, gammaglobulina 19S
Portuguese Imunoglobulinas M, gama Globulina 19S, IgM, Imunoglobulina M