II. Background

  1. Manifestation of Tertiary Syphilis

III. Pathophysiology

  1. Arterial wall medial necrosis and loss of elastic fibers
  2. Typically affects aorta but may affect any part of the Cardiovascular System

IV. Course

  1. Begins 5 to 10 years after initial infection
  2. Clinically seen 20-30 years after infection

V. Signs

  1. Obliterative endarteritis of vasa vasorum
  2. Ascending aorta develops
    1. Aortic Insufficiency
    2. Aortic aneurysm

VI. Labs

VII. Management

VIII. Complications

  1. Aortic Insufficiency
  2. Aorta Rupture

IX. References

  1. Green, Cohen, Billington (2016) Crit Dec Emerg Med 30(11): 4-10

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Related Studies

Ontology: Syphilis, Cardiovascular (C0039130)

Definition (MSH) Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.
Concepts Disease or Syndrome (T047)
MSH D013589
ICD9 093.9, 093
ICD10 A52.0 , I98.0, A52.00
SnomedCT 186883005, 186870009, 154383007, 83883001
English Syphilis, Cardiovascular, Cardiovascular syphilis NOS, Cardiovascular syphilis, unspecified, Cardiovascular Syphilis, cardiovascular syphilis, CV syphilis, cardiovascular syphilis (diagnosis), Cardiovascular syph NOS, Syphilis, Cardiovascular [Disease/Finding], Cardiovascular syphilis NOS (disorder), Cardiovascular syphilis, Cardiovascular syphilis (disorder), cardiovascular; syphilitic (etiology), cardiovascular; syphilitic (manifestation), disease (or disorder); heart, syphilitic (etiology), disease (or disorder); heart, syphilitic (manifestation), syphilis; cardiovascular (etiology), syphilis; cardiovascular (manifestation), Cardiovascular syphilis, NOS
Dutch cardiovasculaire syfilis NAO, cardiovasculaire syfilis, niet-gespecificeerd, aandoening; hart, luetisch, cardiovasculair; syfilis, syfilis; cardiovasculair, cardiovasculaire syfilis, Cardiovasculaire syfilis, Syfilis, cardiovasculaire
French Syphilis cardio-vasculaire SAI, Syphilis cardiovasculaire, non précisée, Syphilis cardiovasculaire, Syphilis cardio-vasculaire
German kardiovaskulaere Syphilis NNB, kardiovaskulaere Syphilis, unspezifisch, Kardiovaskuläre Lues, Kardiovaskuläre Syphilis, Kardiovaskulaere Syphilis, kardiovaskulaere Syphilis, Lues, kardiovaskuläre, Syphilis, kardiovaskuläre
Italian Sifilide cardiovascolare, non specificata, Sifilide cardiovascolare NAS, Sifilide cardiovascolare
Portuguese Sífilis cardiovascular NE, Sífilis cardiovascular, Sífilis Cardiovascular
Spanish Sífilis cardiovascular no especificada, Sífilis cardiovascular NEOM, sífilis cardiovascular, SAI (trastorno), sífilis cardiovascular, SAI, sífilis cardiovascular (trastorno), sífilis cardiovascular, Sífilis cardiovascular, Sífilis Cardiovascular
Japanese 心血管系梅毒、詳細不明, 心血管系梅毒NOS, シンケッカンケイバイドクNOS, シンケッカンケイバイドクショウサイフメイ, シンケッカンケイバイドク, 心臓血管系梅毒, 大動脈炎-梅毒性, 心臓血管梅毒, 梅毒性大動脈炎, 心血管梅毒, 心血管系梅毒, 梅毒-心臓血管系
Swedish Syfilis, kardiovaskulär
Czech syfilis kardiovaskulární, Kardiovaskulární syfilis, blíže neurčená, Kardiovaskulární syfilis NOS, Kardiovaskulární syfilis
Finnish Sydän-verisuonikuppa
Korean 심장혈관 매독
Polish Kiła układu krążenia, Zapalenie aorty kiłowe
Hungarian Szív- és érrendszeri syphilis, nem meghatározott, szív- és érrendszeri syphilis, szív- és érrendszeri syphilis k.m.n.
Norwegian Kardiovaskulær lues, Kardiovaskulær syfilis

Ontology: Syphilitic pericarditis (C0153164)

Concepts Disease or Syndrome (T047)
ICD9 093.81
ICD10 A52.06
SnomedCT 3589003
Italian Pericardite sifilitica
Dutch syfilitische pericarditis, pericarditis syfilitisch
Japanese 梅毒性心膜炎, バイドクセイシンマクエン
English syphilis CV pericarditis, syphilitic pericarditis (diagnosis), syphilitic pericarditis, Pericarditis syphilitic, Syphilitic pericarditis, Syphilitic pericarditis (disorder)
Czech Syfilitická perikarditida
Hungarian syphilises pericarditis, Syphilises pericarditis
Spanish pericarditis sifilítica (trastorno), pericarditis sifilítica, Pericarditis sifilítica
Portuguese Pericardite sifilítica
French Péricardite syphilitique
German Perikarditis durch Syphilis

Ontology: Syphilitic myocarditis (C0153165)

Concepts Disease or Syndrome (T047)
ICD9 093.82
ICD10 A52.06
SnomedCT 186881007, 4082005
Italian Miocardite sifilitica
Dutch syfilitische myocarditis, myocarditis syfilitisch
German syphilitische Myokarditis, Myokarditis syphilitisch
Japanese 梅毒性心筋炎, バイドクセイシンキンエン
English syphilitic myocarditis (diagnosis), syphilitic myocarditis, syphilis CV myocarditis, Myocarditis syphilitic, Syphilitic myocarditis, Syphilitic myocarditis (disorder)
Czech Syfilitická myokarditida
Hungarian Syphilises myocarditis, syphilises myocarditis
Spanish miocarditis sifilítica (trastorno), miocarditis sifilítica, Miocarditis sifilítica
Portuguese Miocardite sifilítica
French Myocardite syphilitique