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Ontology:
enterotoxin B, staphylococcal
(C0059386)
Definition (NCI)
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A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin B (SEB), a gram positive superantigen produced by Staphylococcus aureus, is a potent stimulator of T-cell activation. SEB binds directly to class II major histocompatibility complex (MHC) molecules and the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEB, both CD4+ and CD8+ cells proliferate, secrete cytokines and demonstrate enhanced cytotoxic activity against a broad range of antigens. Co-administration of SEB with interleukin-2 (IL-2) by direct injection into tumor cells, may induce clonal T-cell expansion and potentiate apoptosis of tumor cells, resulting in decreased tumor growth.
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Concepts |
Hazardous or Poisonous Substance
(T131)
, Amino Acid, Peptide, or Protein
(T116)
, Immunologic Factor
(T129)
, Pharmacologic Substance
(T121)
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MSH |
C031818
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English |
staph enterotoxin B, staphylococcal enterotoxin B, enterotoxin B, staphylococcal, SEB superantigen, Staphylococcus enterotoxin B, staph enterotoxin b, staphylococcal enterotoxin b, SEB, Staphylococcal Enterotoxin B |