III. Efficacy

  1. Good benefit in combination with 2 nucleosides

IV. Dosing

  1. Start: 200 mg PO qd for 14 days
  2. If no rash, increase dose to 200 mg PO bid

V. Adverse effects

  1. See NNRTI for class related adverse effects
  2. Severe hepatoxicity and liver failure risk if pre-treatment CD4 >250 in men or >400 in women

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Cost: Medications

nevirapine (on 4/19/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
NEVIRAPINE 200 MG TABLET Generic $0.19 each
NEVIRAPINE ER 400 MG TABLET Generic $10.46 each
viramune (on 1/4/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
VIRAMUNE 200 MG TABLET Generic $0.19 each
VIRAMUNE XR 400 MG TABLET Generic $10.46 each

Ontology: Nevirapine (C0132326)

Definition (NCI) A benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS.
Definition (MSH) A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.
Definition (CSP) potent, non-nucleoside reverse transcriptase inhibitor used, usually in combination with nucleoside analogs, for treatment of HIV infection and AIDS.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D019829
SnomedCT 108704001, 386898005
LNC LP21317-0, MTHU013861
English 6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-, Nevirapine, nevirapine, nevirapine (medication), Nevirapine [Chemical/Ingredient], NEVIRAPINE, 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, NVP, Nevirapine (product), Nevirapine (substance)
Swedish Nevirapin
Czech nevirapin
Finnish Nevirapiini
Japanese ネビラピン
Polish Newirapina
Spanish nevirapina (producto), nevirapina (sustancia), nevirapina, Nevirapina
French Névirapine
German Nevirapin
Italian Nevirapina
Portuguese Nevirapina

Ontology: Viramune (C0728726)

Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH D019829
English viramune, Viramune