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Definition (NCI)
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A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)
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Definition (NCI_NCI-GLOSS)
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A drug used to treat infection caused by viruses.
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Definition (CSP)
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zalcitabine analog
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Definition (MSH)
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A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
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Definition (PDQ)
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A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42593&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42593&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1471" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Nucleic Acid, Nucleoside, or Nucleotide
(T114)
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| MSH |
D019259
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| SnomedCT |
108698001, 386897000 |
| LNC |
LP21312-1, MTHU013847 |
| English |
3TC, 2',3' Dideoxy 3' thiacytidine, 2',3'-Dideoxy-3'-thiacytidine, 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-, Lamivudine, THREE TC, DIDEOXYTHIACYTIDINE 002 003 003, 2'3' dideoxy 3' thiacytidine, lamivudine (medication), LAMIVUDINE, Lamivudine [Chemical/Ingredient], 3tc, lamiVUDine, LamiVUDine, 3'-Thia-2',3'-dideoxycytidine, 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone, lamivudine, Lamivudine (product), Lamivudine (substance) |
| Swedish |
Lamivudin
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| Czech |
lamivudin
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| Finnish |
Lamivudiini
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| Russian |
2',3'-DIDEZOKSI-3'-TIATSITIDIN, LAMIVUDIN, 2',3'-ДИДЕЗОКСИ-3'-ТИАЦИТИДИН, 3TC, ЛАМИВУДИН |
| German |
DREI TC, DIDESOXYTHIACYTIDIN 002 003 003, 3TC, 2'3'-Didesoxy-3'-thiacytidin, Lamivudin |
| Polish |
Lamiwudyna
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| Japanese |
2',3'-ジデオキシ-3'-チアシチジン, ラミブジン |
| Spanish |
lamivudina (producto), lamivudina (sustancia), lamivudina, 3TC, 2',3'-Didesoxi-3'-tiacitidina, Lamivudine |
| French |
3TC, Didésoxy-2',3' thiacytidine-3', Lamivudine |
| Italian |
Lamivudina
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| Portuguese |
3TC, 2',3'-Didesoxi-3'-tiacitidina, Lamivudina |
