II. Preparations
- Emtricitabine (Emtriva, Coviracil)
- Emtricitabine with Tenofovir (Truvada TDF or Descovy TAF)
III. Mechanism
IV. Adverse Effects: Emtricitabine alone
- See nRTI for adverse effects attributed to the class
- Minimal specific adverse effects and well tolerated
- Hyperpigmentation of palms and soles
- Hepatitis B infection flares on withdrawal of medication
V. Adverse Effects: Emtricitabine with Tenofovir (Truvada, Descovy)
- See Tenofovir
- Start-up syndrome (Nausea, Abdominal Pain, Flatulence, Headache) which typically resolves after the first month
-
Hepatitis B
Virus flare
- Associated with abrupt cessation of Antiretroviral therapy
- Acute Renal Failure
VI. Protocol: HIV Prevention
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| truvada (on 3/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TRUVADA 200 MG-300 MG TABLET | $50.46 each | |
| emtriva (on 1/18/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| EMTRIVA 200 MG CAPSULE | $17.19 each | |
| descovy (on 3/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DESCOVY 200-25 MG TABLET | $50.31 each | |
Ontology: emtricitabine (C0909839)
| Definition (NCI) | A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). |
| Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
| MSH | C122114 |
| SnomedCT | 404855005, 404856006 |
| LNC | LP35786-0, MTHU018643 |
| English | 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-, FTC, emtricitabine, emtricitabine (medication), EMTRICITABINE, emtricitabine [Chemical/Ingredient], beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine, Emtricitabine (product), Emtricitabine (substance), Emtricitabine |
| Spanish | emtricitabina (producto), emtricitabina (sustancia), emtricitabina |
