II. Contraindications
- HLA-B*5701 positive state (screen in advance of starting)
- Associated with life-threatening Hypersensitivity
III. Mechanism
IV. Dosing
- Abacavir 300 mg PO bid
V. Precautions
- Do not use unless patient is negative for HLA-B5701
- Risk of Hypersensitivity Reaction if HLA-B5701 positive
- Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]
VI. Adverse Effects
-
Hypersensitivity (3%)
- Presents with Fever and Rash
- Associated with HLA-B*5701 positive state
- Mean onset 11 days after start
- Lethal reaction if restarted after reaction (50%)
- Never rechallenge Abacavir after reaction
- Cardiovascular risk
- Unclear association is being investigated
VII. Resources: Abacavir Hypersensitivity Registry
- Phone: 1-800-270-0425
Images: Related links to external sites (from Bing)
Related Studies
| abacavir (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ABACAVIR 300 MG TABLET | Generic | $2.13 each |
| ABACAVIR-LAMIVUDINE 600-300 MG | Generic | $20.22 each |
| ABACAVIR-LAMIVUDINE-ZIDOV TAB | Generic | $23.45 each |
| ziagen (on 5/18/2016 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ZIAGEN 300 MG TABLET | Generic | $2.13 each |
Ontology: abacavir (C0663655)
| Definition (NCI) | A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. |
| Definition (CSP) | carbocyclic nucleoside with anti-HIV activity. |
| Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
| MSH | C106538 |
| SnomedCT | 391696008, 387005008, 116084008 |
| LNC | LP21306-3, MTHU013841 |
| English | abacavir, abacavir [Chemical/Ingredient], AVACAVIR, 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, Abacavir - chemical (substance), Abacavir - chemical, ABACAVIR, Abacavir (product), Abacavir (substance), Abacavir |
| Spanish | abacavir (producto), abacavir (sustancia), abacavir |
Ontology: Ziagen (C0724476)
| Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
| MSH | C106538 |
| English | Ziagen, GSK brand of abacavir sulfate, ziagen |
