II. Types

  1. Distal Sensory Polyneuropathy (most-common HIV-associated Neuropathy)
    1. Common complication at any stage of HIV Infection
    2. Varicella Zoster Virus (VZV) commonly involved
    3. Toxic Peripheral Neuropathy
      1. HIV Treatment with nRTI agents, especially older agents (e.g. DDI or Didanosine)
  2. Demyelinating Neuropathy
    1. Resembles Guillain-Barre
    2. Seen in early HIV
  3. Ascending sensorimotor Neuropathy with Incontinence or polyradiculopathy
    1. Cytomegalovirus (CMV) infection
      1. May involve the spinal cord segment
      2. May present with a painful extremity

III. Symptoms: Distal Sensory Polyneuropathy

  1. Distal lower extremity numbness, Paresthesias, or pain

IV. Signs: Distal Sensory Polyneuropathy

  1. Decreased ankle Deep Tendon Reflexes
  2. Decreased lower extremity Sensation (esp. sharp and vibratory Sensation)

V. Differential Diagnosis

VI. Management

  1. See Peripheral Neuropathy
  2. General measures
    1. Eliminate Neurotoxins (e.g. older Antiretroviral agents)
    2. Control comorbidities (e.g. Diabetes Mellitus, Alcohol Abuse)
    3. Reduce HIV Viral Load
  3. Symptomatic management
    1. Gabapentin (Neurontin)
    2. Tricyclic Antidepressants

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Related Studies

Ontology: HIV peripheral neuropathy (C1697744)

Concepts Disease or Syndrome (T047)
Dutch perifere neuropathie ten gevolge van HIV
French Neuropathie périphérique liée au VIH
German periphere Neuropathie bei HIV
Italian Neuropatia periferica HIV-correlata
Portuguese Neuropatia periférica ligada ao HIV
Spanish Neuropatía periférica por VIH
Japanese HIV末梢性ニューロパチー, HIVマッショウセイニューロパチー
Czech Periferní neuropatie HIV
Hungarian HIV peripheriás neuropathia
English HIV peripheral neuropathy

Ontology: HIV associated polyneuropathy (C3160946)

Concepts Disease or Syndrome (T047)
English HIV associated polyneuropathy
Spanish Polineuropatía asociada al VIH
Portuguese Polineuropatia associada ao HIV
Italian Polineuropatia associata a HIV
German HIV-assoziierte Polyneuropathie
French Polyneuropathie associée au VIH
Dutch hiv-geassocieerde polyneuropathie
Czech Polyneuropatie související s HIV
Japanese HIV関連多発ニューロパチー, HIVカンレンタハツニューロパチー
Hungarian HIV-el összefüggő polyneuropathia