II. Causes: Thrombocytopenia
- Chemotherapeutic agents
- Alkylating Agents
- Antimetabolites
- Interferon
- Fludarabine
- Oxaliplatin
- Antibiotics
- Sulfonamides (e.g. Bactrim)
- Penicillins
- Cephalosporins
- Rifampin
- Vancomycin
- Fluoroquinolones
- Linezolid
- Ganciclovir
- Cardiovascular Agents
- Abciximab (ReoPro)
- Eptifibatide (Integrilin)
- Tirofiban
- Digoxin
- Methyldopa
- Procainamide
- Cinchona alkaloids (Quinidine, Quinine, Tonic Water)
- Thiazide Diuretics (Hydrochlorothiazide, Chlorthalidone)
- H2 Antagonists
- Neuropsychiatric agents
- Miscellanous Agents
III. Causes: Platelet impaired function
- Common causes
- Other causes
- Antidepressants
- Antihistamines
- Azatadine
- Brompheniramine
- Clemastine fumarate
- Clofibrate
- Dipyridamole
- Furosemide (Lasix)
- Ginkgo Biloba
- Nitrofurantoin (Furadantin)
- Propranolol
- Sulfinpyrazone
IV. Management
- Discontinue offending agent and recheck Platelet Count in 1 week
- See Thrombocytopenia
- See Thrombocytopenia Causes
V. Course
- Onset within 5 to 7 days of starting the medication
- Expect recovery in 7-14 days after discontinuation of medication
VI. References
- Merrill and Gillen (2016) Crit Dec Emerg Med 30(3): 3-8
- Kenney (2009) Arch Pathol Lab Med 133(2): 309-14 [PubMed]
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Concepts | Pathologic Function (T046) |
SnomedCT | 191322006 |
English | Thrombocytopenia (due to): drugs, Thrombocytopenia due to drugs, Thrombocytopenia due to drugs (disorder), drugs; thrombocytopenia, thrombocytopenia; drugs |
Dutch | geneesmiddel; trombocytopenie, trombocytopenie; geneesmiddelen |
Spanish | trombocitopenia medicamentosa (trastorno), trombocitopenia medicamentosa, trombocitopenia por fármacos |
Ontology: Drug Induced Thrombocytopenia (C2063616)
Definition (NCI) | Thrombocytopenia caused by ingested or injected drugs. It may be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction. |
Concepts | Disease or Syndrome (T047) |
English | drug-induced thrombocytopenia (diagnosis), drug-induced thrombocytopenia, Drug Induced Thrombocytopenia, DITP, Drug-Induced Immune Thrombocytopenia |