II. Preparations: Traditional Chemotherapy

  1. Alkylating Agent
  2. Antimetabolite Chemotherapy
  3. Hormonally Active Chemotherapy
  4. Plant Alkaloid Chemotherapy
  5. Antibiotic Chemotherapy
  6. Miscellaneous Medication
    1. Amsacrine
    2. Asparaginase
    3. Hydoxyurea
    4. Mitoxantrone
    5. Mitotane (Lysodren)
    6. Quinacrine

IV. Management: General

  1. See Cancer Symptom
  2. Exercise encouraged following high dose Chemotherapy
    1. Safe
    2. Prevents deconditioning
    3. Decreases toxic side effects of Chemotherapy
    4. Dimeo (1997) Blood 90:3390-4 [PubMed]

V. Management: Extravasation of agents from IV

  1. Practice vigilent prevention
  2. Findings: Onset with hours of Chemotherapy
    1. Early: Pain, local erythema and swelling
    2. Later: Blanching, Blistering, discoloration and tissue necrosis
  3. Management: Early recognition and treatment is critical
    1. Immediately stop any infusion
    2. Leave cannula in place until management plan is established
    3. Apply ice to area
    4. Do not compress area
    5. Use antidotes if available
    6. Urgent Consultations with Oncology and Surgery
      1. Debridement with skin grafting may be needed
  4. Complications
    1. Scarring
    2. Contractures
    3. Amputation
  5. References
    1. Higdon (2006) Am Fam Physician 74:1873-80 [PubMed]
    2. Higdon (2018) Am Fam Physician 97(11):741-8 [PubMed]

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Related Studies

Ontology: Pharmacotherapy (C0013216)

Definition (MSH) The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
Definition (NCI) Treatment of disease through the use of drugs.
Definition (NCI_NCI-GLOSS) Treatment with any substance, other than food, that is used to prevent, diagnose, treat, or relieve symptoms of a disease or abnormal condition.
Definition (PSY) Mandatory term applied to studies dealing with the use of drugs in the clinical treatment of diseases or psychological disorders. Used for human or animal populations. For the use of drugs in non-clinical contexts, use PHARMACOLOGY or PSYCHOPHARMACOLOGY.
Definition (HL7V3.0) <p>The introduction of a drug into a subject with the intention of altering its biologic state with the intent of improving its health status.</p>
Concepts Therapeutic or Preventive Procedure (T061)
MSH D004358
SnomedCT 416608005, 182915007, 182831000, 266814004, 151196004
English Drug Therapies, Drug Therapy, Pharmacotherapies, Pharmacotherapy, Therapies, Drug, Therapy, Drug, pharmacotherapy, Drug therapy NOS, Pharmacological Treatment, Treatment With Medication, PHARMACOTHER, DRUG THER, THER DRUG, DT - Drug therapy, drug treatment (drug therapy), drugs therapies, medication therapy, drug therapies, pharmacotherapies, therapy medication, drug therapy, medications therapy, pharmacotherapeutics, drug therapy treatment, Medication therapy, Drug therapy NOS (procedure), Therapy (Drug), Pharmacological Treatments, Drug therapy, Drug therapy (procedure)
French Chimiothérapie, Traitement médicamenteux, Traitement par des médicaments, Thérapie médicamenteuse, Thérapie par des médicaments, Pharmacothérapie
Swedish Läkemedelsterapi
Japanese ヤクブツリョウホウ, 化学療法, 薬物療法, 投薬, 薬物治療
Czech farmakoterapie, Léková terapie, chemoterapie, terapie léky
Finnish Lääkehoito
Italian Chemioterapia, Farmacoterapia, Terapia farmacologica
Spanish tratamiento farmacológico, tratamiento farmacológico (procedimiento), farmacoterapia, farmacoterapia, SAI (procedimiento), farmacoterapia, SAI, quimioterapia, farmacoterapia (procedimiento), Drug therapy NOS, Tratamiento farmacológico, Farmacoterapia, Quimioterapia
Polish Farmakoterapia, Leczenie farmakologiczne
Hungarian Gyógyszeres kezelés
Norwegian Kjemoterapi, Farmakoterapi, Medikamentell behandling
Portuguese Tratamento Medicamentoso, Tratamento farmacológico, Farmacoterapia, Quimioterapia
Dutch geneesmiddelentherapie, Chemotherapie, Farmacotherapie, Therapie, medicamenteuze
German Therapie mit Medikamenten, Arzneimitteltherapie, Chemotherapie, Pharmakotherapie, Medikamentöse Therapie, Therapie, medikamentöse