II. Causes: Tender Regional Unilateral Lymphadenopathy

III. Causes: Right Supraclavicular Nodes

  1. Drainage Patterns
    1. Mediastinum
    2. Lungs
    3. Esophagus
  2. Lymphadenopathy Causes
    1. Lung Cancer
    2. Gastrointestinal cancer
    3. Cancer of the Retroperitoneum

IV. Causes: Left Supraclavicular Nodes

  1. Drainage Patterns
    1. Thorax
    2. Abdomen (Thoracic Duct drainage)
  2. Lymphadenopathy Causes (See Virchow's Node)
    1. Lymphoma
    2. Cancer of the thorax
    3. Cancer of the Retroperitoneum
    4. Bacterial Infection
    5. Fungal infection

V. Causes: Infraclavicular Nodes

  1. Highly associated with Non-Hodgkin Lymphoma

VI. Causes: Axillary Nodes

VII. Causes: Epitrochlear Nodes (proximal to elbow medial epicondyle)

  1. Drainage Patterns
    1. Ulnar Forearm
    2. Ulnar hand
    3. Pinky and ring finger
  2. Lymphadenopathy Causes
    1. Miscellaneous infectious causes
    2. Lymphoma
    3. Sarcoidosis
    4. Tularemia
    5. Secondary Syphilis

VIII. Causes: Inguinal Nodes

  1. Drainage Patterns
    1. Horizontal Group (along inguinal ligament, at midline thigh)
      1. Skin of lower anterior abdominal wall
      2. Retroperitoneal drainage
      3. Penis and Scrotum
      4. Vulva and vagina
      5. Gluteal region
      6. Lower anal canal
      7. Perineum
    2. Vertical Group (along upper great saphenous vein, at medial thigh)
      1. Penis and Scrotum
      2. Gluteal region
      3. Lower limb drainage
  2. Lymphadenopathy Causes
    1. Infections of the leg and foot
    2. Lymphoma
    3. Kaposi Sarcoma
    4. Pelvic malignancy
    5. Bubonic Plague
    6. Tuberculosis
    7. Squamous Cell Carcinoma (penis, vulva, anus)
    8. Sexually Transmitted Diseases
      1. Herpes Simplex Virus
      2. Gonorrhea
      3. Syphilis
      4. Chancroid
      5. Granuloma Inguinale
      6. Lymphogranuloma venereum
  3. Non-Causes
    1. Testicular Cancer metastasizes to para-aortic nodes

IX. References

  1. Degowin (1987) Diagnostic Exam, Macmillan, p. 467
  2. Dornbland (1992) Adult Ambulatory Care, p. 662-7
  3. Lee (1999) Wintrobe's Hematology, p. 1826-30
  4. Wilson (1991) Harrison's Internal Medicine, p. 354-6
  5. Ferrer (1998) Am Fam Physician 58(6): 1313-2 [PubMed]
  6. Gaddey (2016) Am Fam Physician 94(11): 896-903 [PubMed]
  7. Habermann (2000) Mayo Clin Proc 75:728 [PubMed]

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Related Studies

Ontology: Axillary lymphadenopathy (C0578735)

Definition (NCI) A clinical finding indicating the enlargement of the lymph nodes in the axillary region. It may be caused by infections, systemic diseases, or cancer.
Concepts Pathologic Function (T046)
SnomedCT 127189005
Dutch oksellymfadenopathie, oksellymfeklieren vergroot, okseladenopathie
French Ganglions lymphatiques axillaires hypertrophiés, Adénopathie axillaire, Lymphadénopathie axillaire
German axillaere Adenopathie, axillaere Lymphknoten vergroessert, Lymphadenopathie axillaer
Italian Adenopatia ascellare, Linfadenopatia ascellare, Linfonodi ascellari ingrossati
Portuguese Gânglios linfáticos aumentados de volume, Adenopatia axilar, Linfadenopatia axilar
Spanish Ganglios linfáticos axilares agrandados, Linfadenopatía axilar, Adenopatía axilar, linfadenopatía axilar (trastorno), linfadenopatía axilar
Japanese 腋窩リンパ節腫大, 腋窩リンパ節症, 腋窩アデノパシー, エキカアデノパシー, エキカリンパセツシュダイ, エキカリンパセツショウ
English axillary lymphadenopathy, axillary lymph nodes enlarged, Axillary lymphadenopathy, Axillary adenopathy, Axillary lymph nodes enlarged, enlarged axillary lymph node, enlarged axillary lymph node (physical finding), axillary adenopathy, Lymphadenopathy axillary, Enlargement of axillary lymph node, Axillary lymphadenopathy (disorder), Axillary Adenopathy, Axillary Lymphadenopathy
Czech Axilární lymfadenopatie, Zvětšené axilární lymfatické uzliny
Hungarian Axillaris nyirokcsomók megnagyobbodottak, Axillaris adenopathia, Lymphadenopathia axillaris

Ontology: Inguinal lymphadenopathy (C0578736)

Concepts Disease or Syndrome (T047)
SnomedCT 127199000
Dutch lieslymfadenopathie
French Lymphadénopathie inguinale
German Lymphadenopathie inguinal
Italian Linfadenopatia inguinale
Portuguese Linfadenopatia inguinal
Spanish Linfadenopatía inguinal, linfadenopatía inguinal (trastorno), linfadenopatía inguinal
Japanese 鼡径部リンパ節症, ソケイブリンパセツショウ
English inguinal lymphadenopathy, inguinal lymph nodes enlarged, Lymphadenopathy inguinal, enlarged inguinal lymph node (physical finding), enlarged inguinal lymph node, Groin lymphadenopathy, inguinal lymph node enlargement, Enlargement of inguinal lymph node, Inguinal lymphadenopathy, Inguinal lymphadenopathy (disorder)
Czech Inguinální lymfadenopatie
Hungarian Inguinalis lymphadenopathia

Ontology: Epitrochlear lymphadenopathy (C0578738)

Concepts Sign or Symptom (T184)
SnomedCT 127197003
English Epitrochlear lymphadenopathy, Epitrochlear lymphadenopathy (disorder)
Spanish linfadenopatía epitroclear (trastorno), linfadenopatía epitroclear