II. Characteristics

  1. Forms in Bone Marrow from Myeloblasts as with other Granulocytes (Neutrophils, Eosinophils, Monocytes)
  2. Basophil granules contain Heparin, vasoactive amines (histamines, 5-Hydroxytryptamine)
    1. Released agents increase vascular permeability, allowing inflammatory agents to reach injured tissue
  3. Function: Immediate Allergic Response
    1. Similar mechanism of action to Mast Cells
    2. Related to delayed Hypersensitivity response
    3. Activated on binding IgE-Antigen complexes via high affinity receptors (FceRI)
    4. Activation results in release of inflammatory mediators contained in its secretory granules
      1. Immediate release of preformed mediators (e.g. Histamine, Bradykinin) within first 5 minutes
      2. Leukotriene C4 released within 5-30 minutes, and results in bronchoconstriction
      3. Releases Cytokines TNF-alpha and IL4 within hours
      4. Chemotactic factors attract Neutrophil, Eosinophil

III. Labs: Morphology on Blood Smear

  1. Granulocyte cytoplasm stains darkly with Wright Stain
  2. Two lobed nucleus
  3. Diameter: 5-7 microns

IV. Interpretation: Normal Levels

  1. Range: 0.4-1.0% (Least common Leukocyte)

V. Causes: Increased Basophils (Basophilia)

  1. Viral Infections (e.g. Varicella)
  2. Hodgkin's Lymphoma
  3. Hemolytic Anemia
  4. Following splenectomy
  5. Myeloproliferative disease
    1. Chronic Myelogenous Leukemia
    2. Polycythemia Vera
    3. Myelofibrosis
  6. Inflammatory processes
    1. Inflammatory Bowel Disease
    2. Chronic dermatitis
    3. Asthma
    4. Chronic Sinusitis
  7. Endocrine causes
    1. Hypothyroidism
    2. Increased Estrogen

VI. Causes: Decreased Basophils

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Related Studies

Ontology: Basophils (C0004827)

Definition (MSHCZE) Bazofilní granulocyt. Druh bílé krvinky (leukocytu), jehož funkce není zcela jasná, snad ovlivňuje srážení krve v místě zánětu. Při vyšetření diferenciálu je b. nejméně četným druhem, krvinka se „ráda“ barví zásaditým barvivem. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI_NCI-GLOSS) A type of immune cell that has granules (small particles) with enzymes that are released during allergic reactions and asthma. A basophil is a type of white blood cell and a type of granulocyte.
Definition (MSH) Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
Definition (CSP) granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes; contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation.
Concepts Cell (T025)
MSH D001491
SnomedCT 30061004
LNC LP14328-6, LP21273-5, MTHU012774
English Basophils, Basophil, segmented, basophilic granulocyte, basophilic leukocyte, Basophil leukocyte, basophils, basophil, Basophil, Basophil, segmented (cell)
Spanish basófilo, segmentado, basófilo, segmentado (célula), basófilo, granulocito basófilo, Basófilos
French Polynucléaires basophiles, Granulocyte basophile, PNB (Polynucléaire Basophile), Basophiles, Polynucléaire basophile, Granulocytes basophiles
Swedish Basofiler
Czech bazofily, granulocyty bazofilní
Finnish Basofiilit
Latvian Bazofili
Polish Bazofile, Granulocyty zasadochłonne
Norwegian Basofile leukocytter, Leukocytter, basofile, Basofile celler
German Basophile Leukozyten, Basophile
Italian Basofili
Dutch Basofiel, Basofiele leukocyt, Basofielen
Portuguese Basófilos

Ontology: Blood basophil count (lab test) (C0200641)

Concepts Laboratory Procedure (T059)
SnomedCT 165529004, 142941000, 165526006, 142937004, 42351005
English Basophils, Basophil count NOS, blood basophil count, blood basophil count (lab test), basophil count, Blood basophil count (lab test), basophils count, Basophil count NOS (procedure), Basophil count, Basophil count (procedure), Basophil count [dup] (procedure)
Italian Conta basofila, Basofili
Dutch basofielen, basofielentelling
French Basophiles, Numération des basophiles
German basophile Granulozyten, Basophilenzahl
Portuguese Basófilos, Número de basófilos
Spanish Basófilos, recuento de basófilos, SAI (procedimiento), recuento de basófilos, SAI, Basophil count NOS, recuento de basófilos (procedimiento), recuento de basófilos, Recuento de basófilos
Japanese 好塩基球, 好塩基球数, コウエンキキュウスウ, コウエンキキュウ
Czech Bazofily, Počet bazofilů
Hungarian Bazofilek, Bazofil szám

Ontology: Basophilia (C0702266)

Concepts Finding (T033)
ICD9 288.65
ICD10 D72.824
SnomedCT 142939001, 65209002
English BASOPHILIA, basophilia, basophilia (diagnosis), basophilic leukocytosis, basophilia disorder, basophilia test result, Circulating basophils increased above normal range, Basophilic leukocytosis, Basophilia (finding), Basophilic leucocytosis, Basophilia
Italian Basofilia
Japanese 好塩基球増加症, コウエンキキュウゾウカショウ
Portuguese BASOFILIA, Basofilia
Spanish BASOFILIA, basofilia (hallazgo), basofilia, leucocitosis con basofilia, Basofilia
French BASOPHILIE, Basophilie
German BASOPHILIE, Basophilie
Czech Bazofilie
Hungarian basophilia
Dutch basofilie