II. Pathophysiology

III. Epidemiology

  1. Heterozygotes have 25-50% ATIII functional levels
  2. First episode of thrombosis occurs ages 10-30 years

IV. Complications

V. Labs

  1. Functional level Antithrombin III

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Ontology: Antithrombin III Deficiency (C0272375)

Definition (NCI) A rare disorder characterized by the presence of low levels of antithrombin III which prohibits the formation of blood clots. It may be inherited, usually in an autosomal dominant pattern, or acquired. It may lead to venous thrombosis and pulmonary embolism.
Definition (MSH) An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.
Concepts Disease or Syndrome (T047)
MSH D020152
ICD10 D68.59
SnomedCT 36351005
English AT def - Antithrombin defi, Antithrombin III Deficiency, ANTITHROMBIN III DEFIC, DEFIC ANTITHROMBIN III, ANTITHROMBIN 3 DEFIC, Antithrombin 3 Deficiencies, Antithrombin 3 Deficiency, Deficiencies, Antithrombin 3, Deficiency, Antithrombin 3, Antithrombin III Deficiencies, Deficiencies, Antithrombin III, Deficiency, Antithrombin III, AT-III deficiency, antithrombin III deficiency, antithrombin III deficiency (diagnosis), Antithombin III deficiency, ANTITHROMBIN III DEFICIENCY, Antithrombin III Deficiency [Disease/Finding], antithrombin 3 deficiency, antithrombin deficiency, antithrombin deficiencies, antithrombin iii deficiency, AT3D, THROMBOPHILIA DUE TO ANTITHROMBIN III DEFICIENCY, THPH7, Antithrombin III deficiency, AT deficiency - Antithrombin deficiency, Antithrombin deficiency, Antithrombin III deficiency (disorder)
Japanese アンチトロンビンIII欠乏症, アンチトロンビン3ケツボウショウ, Antithrombin III欠損症, アンチトロンビンIII欠損症, AT3欠損症, アンチトロンビン3欠乏症, アンチトロンビン3欠損症, アンチトロンビンIII欠乏症
Swedish Antitrombin III-brist
Czech antithrombin III - nedostatek, Deficit antitrombinu III
Finnish Antitrombiini III:n puutos
Polish Niedobór antytrombiny III
Hungarian Antithrombin-III-hiány
Norwegian Antitrombin-III-mangel, Antitrombin III-mangel, Antitrombin-3-mangel, Antitrombin 3-mangel
Spanish deficiencia de antitrombina III (trastorno), deficiencia de antitrombina III, Déficit de antitrombina III, Deficiencia de Antitrombina III
Portuguese Carência de antitrombina III, Deficiência de Antitrombina III
Dutch antitrombine III-deficiëntie, Antitrombine-III-deficiëntie, Deficiëntie, antitrombine-III-
French Déficit en antithrombine III, Déficit en AT III, Déficit en AT3, Déficit en antithrombine 3
German Antithrombin-III-Mangel
Italian Deficit di antitrombina III