II. Indications
III. Contraindications
- Renal Insufficiency
- Hepatic insufficiency
- Adrenal Insufficiency
IV. Mechanism: Drosperinone
- Newer synthetic Progestin
- Antiandrogenic activity similar to Progesterone
- Lowest Androgenic Activity
- Marginal benefit over other low androgen OCPs
- Antimineralcorticoid effect (Related to Spironolactone)
- Only OCP Progestin with antimineralcorticoid activity
- Drospirenone 3 mg is equivalent to 25 mg Spironolactone
V. Efficacy
- Similar to other Oral Contraceptives
VI. Formulations
- Yaz
- Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
- Taken for 24 active days and 4 Placebo days
- Yasminelle
- Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
- Taken for 21 active days and 7 Placebo days
- Yasmin, Ocella or Zarah
- Contains 3 mg drospirenone and 30 mcg Ethinyl Estradiol
- Nextstellis
- Contains 3 mg drospirenone and 14.2 mg Estetrol (in mg, NOT mcg)
- Taken for 24 active days and 4 Placebo days
- At time of release in 2021, very expensive (approaching $200/month compared with <$10 for generics)
- Estetrol is a new plant-derived Estrogen (E4) formulation
- References
- (2021) Presc Lett 28(7): 38
VII. Drug Interactions: Potassium retention effects
VIII. Monitoring: Serum Potassium in first month
- Indicated if concurrent use of drugs listed above
IX. Adverse Effects
- See Oral Contraceptive
- Potassium retention (see above)
- May be associated with higher Thromboembolism risk
X. Advantages
- May be associated with less weight gain than other OCP
- As effective as other OCPs in Acne Vulgaris
- May be useful in Polycystic Ovary Disease
- Spironolactone used for associated Hirsutism
XI. References
Images: Related links to external sites (from Bing)
Related Studies
| yasmin (on 9/21/2016 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| YASMIN 28 TABLET | Generic | $0.86 each |
| yaz (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| YAZ 28 TABLET | Generic | $1.19 each |
| ocella (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| OCELLA 3 MG-0.03 MG TABLET | Generic | $0.86 each |
| zarah (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ZARAH TABLET | Generic | $0.86 each |
Ontology: Yasmin (C0939533)
| Concepts | Pharmacologic Substance (T121) , Hormone (T125) , Organic Chemical (T109) |
| MSH | C534342 |
| English | Yasmin, yasmin |
