Gonadotropin-releasing Hormone Agonist

Aka: Gonadotropin-releasing Hormone Agonist, GnRH agonist, Nafarelin Acetate, Synarel

II. Indication

  1. Endometriosis

III. Pathophysiology

  1. Potentiates Gonadotropin-releasing hormone (GnRH)
  2. Results in hypoestrogenism or pseudo-Menopause
  3. Does not cause the same androgenic effects as Danazol

IV. Dosing: Nafarelin Acetate (Synarel)

  1. Synarel 200-400 micro-g intranasally bid

V. Efficacy

  1. Effective at regression of lesions and relief of pain
  2. No proven effect on fertility

VI. Adverse effects

  1. Menopausal symptoms
    1. Hot Flashes
    2. Insomnia
    3. Emotional changes
  2. Bone density loss with prolonged use

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Related Studies

Ontology: Synarel (C0131793)

Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116)
MSH D017274
French Synarel
English synarel, Synarel
Norwegian Synarel
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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