II. Causes: Medication Class

III. Causes: Osmotic Diarrhea

  1. Magnesium containing preparations (Antacids, Laxatives)
  2. Citrates
  3. Phosphates
  4. Sulfates
  5. Sugar Alcohols
    1. Mannitol
    2. Sorbitol
    3. Xylitol

IV. Causes: Secretory Diarrhea

  1. Antiarrhythmics (Quinidine, Digoxin)
  2. Amoxicillan-Clavulanate (Augmentin)
  3. Chemotherapeutic agents
  4. Metformin (Glucophage)
  5. Calcitonin
  6. Colchicine
  7. NSAIDs
  8. Misoprostol

V. Causes: Increased Motility

  1. Macrolides (e.g. Erythromycin)
  2. Metoclopramide (Reglan)
  3. Stimulant Laxatives (e.g. Bisacodyl, senna)

VII. References

  1. Schiller in Feldman (2002) Sleisenger GI, p. 136
  2. Burgers (2020) Am Fam Physician 101(8): 472-80 [PubMed]

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