Indirect Bilirubin

Aka: Indirect Bilirubin, Unconjugated Bilirubin, Hemolytic Jaundice, Unconjugated Hyperbilirubinemia

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II. Interpretation

  1. Normal: <1.0 mg/dl

III. Causes: Increased (Unconjugated Hyperbilirubinemia)

  1. Increased Bilirubin production
    1. Hemolytic Anemia (typically mild Hyperbilirubinemia)
    2. Large heme load (e.g. large Hematoma reabsorption)
    3. Rhabdomyolysis
    4. Hyperthyroidism (Thyrotoxicosis)
    5. Ineffective Erythropoiesis (increased RBC destruction in marrow)
      1. Thalassemia
      2. Pernicious Anemia
      3. Sickle Cell Anemia
      4. Lead Poisoning
      5. Iron Deficiency Anemia
      6. Myeloproliferative Disorder
  2. Defective Bilirubin conjugation
    1. Neonatal Jaundice (immature liver)
    2. Gilbert's disease
    3. Crigler-Najjar syndrome
  3. Impaired hepatic uptake of Bilirubin
    1. Medications (e.g. Gemfibrozil, Indinavir)
    2. Portosystemic shunt
    3. Hepatic congestion (e.g .CHF, liver disease)

IV. References

  1. Fargo (2017) Am Fam Physician 95(3): 164-8 [PubMed]

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Related Studies

Ontology: Jaundice, Hemolytic (C0242183)

Concepts Disease or Syndrome (T047)
MSH D007565 , D000743
SnomedCT 60217008
Dutch geelzucht hemolytisch, hemolytische geelzucht, geelzucht; hemolytisch, hemolytisch; geelzucht, hemolytisch; icterus, icterus; hemolytisch, Icterus, hemolytische
German Gelbsucht haemolytisch, Ikterus, hämolytischer, Hämolytischer Ikterus, Icterus haemolyticus
Portuguese Icterícia hemolítica, Icterícia Hemolítica
Spanish Ictericia hemolítica, Ictericia Hemolítica, ictericia hemolítica (trastorno), ictericia hemolítica
Japanese 溶血性黄疸, ﾖｳｹﾂｾｲｵｳﾀﾞﾝ
Czech Hemolytická žloutenka, Hemolytická icterus, žloutenka hemolytická
English Jaundice haemolytic, Jaundice hemolytic, jaundice hemolytic, Jaundice;haemolytic, hemolytic jaundice, Hemolytic Jaundices, Jaundice, Hemolytic, Jaundices, Hemolytic, Hemolytic jaundice, Haemolytic jaundice, Hemolytic jaundice (disorder), hemolytic; icterus, hemolytic; jaundice, icterus; hemolytic, jaundice; hemolytic, Hemolytic Jaundice, Jaundice;hemolytic, haemolytic jaundice
Hungarian Sárgaság haemolyticus, Sárgaság, haemolytikus
French Ictère hémolytique, Jaunisse hémolytique
Italian Ittero emolitico
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Indirect reacting bilirubin (C0301719)

Concepts Biologically Active Substance (T123) , Organic Chemical (T109)
SnomedCT 37852002, 79706000
English Indirect reacting bilirubin, indirect bilirubin, bilirubin indirect, unconjugated bilirubin, Indirect (Unconjugated) Bilirubin, Unconjugated bilirubin, Indirect bilirubin, BU - Bilirubin, UCB - Unconjugated bilirubin, UCBR - Unconjugated bilirubin, Indirect reacting bilirubin (substance)
Spanish bilirrubina de reacción indirecta (sustancia), bilirrubina de reacción indirecta, bilirrubina no conjugada
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pathology and Laboratory Medicine

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