Intraocular Prostaglandin

Aka: Intraocular Prostaglandin, Latanoprost, Xalatan, Bimatoprost, Lumigan, Travoprost, Travatan, Unoprostone, Rescula, Tafluprost, Zioptan, Vyzulta

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II. Indication

  1. First line agent for Open Angle Glaucoma

III. Mechanism

  1. Prostaglandin analogs that increase aqueous outflow

IV. Agents

  1. Latanoprost (Xalatan) 0.005% one drop daily
  2. Bimatoprost (Lumigan) 0.03% one drop daily
  3. Travoprost (Travatan) 0.004% one drop daily
  4. Unoprostone (Rescula) 0.15% one drop daily
  5. Tafluprost (Zioptan) 0.0015% one drop daily
  6. Latanoprostene bunod (Vyzulta)
    1. Breaks down to Latanoprost and nitric oxide, but with no significant benefit over Latanoprost alone
    2. Released in 2018, costing 10x the cost of Latanoprost alone (which is $12 per bottle)
    3. (2018) Presc Lett 25(5): 28

V. Efficacy: Latanoprost

  1. Highly effective, low side effect agent
  2. Currently most prescribed Glaucoma agent worldwide
  3. References
    1. Hedman (2000) Eur J Ophthalmol 10:95-104 [PubMed]

VI. Adverse Effects

  1. Increased eyelash growth
  2. Eyelid fat atrophy (with secondary Eyelid droop or Ptosis)
  3. Increased pigmentation of iris, Eyelid or eyelashes

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Cost: Medications

latanoprost (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
LATANOPROST 0.005% EYE DROPS Generic $2.10 per ml
xalatan (on 6/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
XALATAN 0.005% EYE DROPS Generic $2.10 per ml
bimatoprost (on 3/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
BIMATOPROST 0.03% EYE DROPS Generic $34.15 per ml
BIMATOPROST 0.03% EYELASH SOLN Generic $28.42 per ml
lumigan (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
LUMIGAN 0.01% EYE DROPS $63.23 per ml
travoprost (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
TRAVOPROST 0.004% EYE DROP Generic $30.21 per ml
travatan (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
TRAVATAN Z 0.004% EYE DROP $60.10 per ml
zioptan (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
ZIOPTAN 0.0015% EYE DROPS $5.64 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: latanoprost (C0090306)

Definition (NCI) A prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C072042
SnomedCT 330728002, 108838001, 386926002
English latanoprost, Latanoprost [eye], latanoprost (ophthalmic) (medication), latanoprost (ophthalmic), latanoprost ophthalmic, latanoprost [Chemical/Ingredient], Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate, LATANOPROST, Latanoprost Ophthalmic, Latanoprost [eye] (product), Latanoprost, Latanoprost (product), Latanoprost (substance), Latanoprost [eye] (substance)
Spanish latanoprost (ocular) (producto), latanoprost (ocular), latanoprost (producto), latanoprost (sustancia), latanoprost
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Xalatan (C0593887)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C072042
LNC LA14718-3
English Pfizer brand of latanoprost, xalatan, Xalatan®, Xalatan
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: UNOPROSTONE (C0772319)

Concepts Pharmacologic Substance (T121) , Hormone (T125) , Eicosanoid (T111)
English unoprostone, UNOPROSTONE, Unoprostone
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: travoprost (C0937916)

Definition (NCI) A synthetic lipophilic isopropyl ester prodrug of the active compound travoprost free acid, a prostaglandin F2alpha analog with anti-glaucoma property. Upon administration, travoprost is hydrolysed to a free acid by corneal esterases, and then selectively stimulating the prostaglandin F (FP prostanoid) receptor, thereby increasing the uveoscleral outflow which leads to a reduction in intra-ocular pressure.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C438103
SnomedCT 391664000, 129493000
English TRAVOPROST @ @ UNIDENTIFIED, TRAVOPROST UNIDENTIFIED, 5-Heptenoic Acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester,(5Z)-, travoprost (ophthalmic) (medication), travoprost (ophthalmic), travoprost [Chemical/Ingredient], TRAVOPROST, travoprost, travoprost ophthalmic, Travoprost (product), Travoprost (substance), Travoprost
Spanish travoprost (producto), travoprost (sustancia), travoprost
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: bimatoprost (C0937917)

Definition (NCI_NCI-GLOSS) A drug used under the name Latisse to increase the length, thickness, and darkness of eyelashes. It is being studied as a way to increase the growth of eyelashes and eyebrows in patients given chemotherapy for cancer. Bimatoprost is also used under the name Lumigan to treat glaucoma (a build-up of fluid in the eye). It lowers pressure in the eye by increasing the flow of natural eye fluids out of the eye. It is a type of prostaglandin analog.
Definition (NCI) A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intraocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors.
Concepts Eicosanoid (T111) , Pharmacologic Substance (T121)
MSH C420823
SnomedCT 129492005, 395300006
English BIMATOPROST @ @ UNIDENTIFIED, BIMATOPROST UNIDENTIFIED, 5-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-,(5Z)-, 5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))-, bimatoprost (medication), bimatoprost [Chemical/Ingredient], bimatoprost, Bimatoprost, Bimatoprost (product), Bimatoprost (substance), BIMATOPROST
Spanish bimatoprost (producto), bimatoprost (sustancia), bimatoprost
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Lumigan (C0939372)

Concepts Eicosanoid (T111) , Pharmacologic Substance (T121)
MSH C420823
English Lumigan, lumigan, Pharm-Allergan brand of bimatoprost, Allergan brand of bimatoprost
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Eescula (C0939466)

Concepts Pharmacologic Substance (T121) , Eicosanoid (T111)
MSH C072630
English Eescula, rescula, Rescula, Ciba Vision brand of isopropyl unoprostone, Novartis brand of isopropyl unoprostone
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Travatan (C0939506)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C438103
English Travatan, travatan, Alcon brand of travoprost
Derived from the NIH UMLS (Unified Medical Language System)

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