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Ontology:
latanoprost
(C0090306)
Definition (NCI)
|
A prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C072042
|
SnomedCT |
330728002, 108838001, 386926002 |
English |
latanoprost, Latanoprost [eye], latanoprost (ophthalmic) (medication), latanoprost (ophthalmic), latanoprost ophthalmic, latanoprost [Chemical/Ingredient], Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate, LATANOPROST, Latanoprost Ophthalmic, Latanoprost [eye] (product), Latanoprost, Latanoprost (product), Latanoprost (substance), Latanoprost [eye] (substance) |
Spanish |
latanoprost (ocular) (producto), latanoprost (ocular), latanoprost (producto), latanoprost (sustancia), latanoprost |
Ontology:
Xalatan
(C0593887)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C072042
|
LNC |
LA14718-3 |
English |
Pfizer brand of latanoprost, xalatan, Xalatan®, Xalatan |
Ontology:
UNOPROSTONE
(C0772319)
Concepts |
Pharmacologic Substance
(T121)
, Hormone
(T125)
, Eicosanoid
(T111)
|
English |
unoprostone, UNOPROSTONE, Unoprostone |
Ontology:
travoprost
(C0937916)
Definition (NCI)
|
A synthetic lipophilic isopropyl ester prodrug of the active compound travoprost free acid, a prostaglandin F2alpha analog with anti-glaucoma property. Upon administration, travoprost is hydrolysed to a free acid by corneal esterases, and then selectively stimulating the prostaglandin F (FP prostanoid) receptor, thereby increasing the uveoscleral outflow which leads to a reduction in intra-ocular pressure.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C438103
|
SnomedCT |
391664000, 129493000 |
English |
TRAVOPROST @ @ UNIDENTIFIED, TRAVOPROST UNIDENTIFIED, 5-Heptenoic Acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester,(5Z)-, travoprost (ophthalmic) (medication), travoprost (ophthalmic), travoprost [Chemical/Ingredient], TRAVOPROST, travoprost, travoprost ophthalmic, Travoprost (product), Travoprost (substance), Travoprost |
Spanish |
travoprost (producto), travoprost (sustancia), travoprost |
Ontology:
bimatoprost
(C0937917)
Definition (NCI_NCI-GLOSS)
|
A drug used under the name Latisse to increase the length, thickness, and darkness of eyelashes. It is being studied as a way to increase the growth of eyelashes and eyebrows in patients given chemotherapy for cancer. Bimatoprost is also used under the name Lumigan to treat glaucoma (a build-up of fluid in the eye). It lowers pressure in the eye by increasing the flow of natural eye fluids out of the eye. It is a type of prostaglandin analog.
|
Definition (NCI)
|
A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intraocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors.
|
Concepts |
Eicosanoid
(T111)
, Pharmacologic Substance
(T121)
|
MSH |
C420823
|
SnomedCT |
129492005, 395300006 |
English |
BIMATOPROST @ @ UNIDENTIFIED, BIMATOPROST UNIDENTIFIED, 5-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-,(5Z)-, 5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))-, bimatoprost (medication), bimatoprost [Chemical/Ingredient], bimatoprost, Bimatoprost, Bimatoprost (product), Bimatoprost (substance), BIMATOPROST |
Spanish |
bimatoprost (producto), bimatoprost (sustancia), bimatoprost |
Ontology:
Lumigan
(C0939372)
Concepts |
Eicosanoid
(T111)
, Pharmacologic Substance
(T121)
|
MSH |
C420823
|
English |
Lumigan, lumigan, Pharm-Allergan brand of bimatoprost, Allergan brand of bimatoprost |
Ontology:
Eescula
(C0939466)
Concepts |
Pharmacologic Substance
(T121)
, Eicosanoid
(T111)
|
MSH |
C072630
|
English |
Eescula, rescula, Rescula, Ciba Vision brand of isopropyl unoprostone, Novartis brand of isopropyl unoprostone |
Ontology:
Travatan
(C0939506)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C438103
|
English |
Travatan, travatan, Alcon brand of travoprost |