II. Preparations

  1. Apraclonidine (Lopidine)
  2. Brimonidine (Alphagan)
    1. Available as combination with Brinzolamide (Simbrinza)
    2. Mirvaso (Brimonidine gel)
      1. Indicated for Eye Redness due to Rosacea
    3. Lumify (OTC Brimonidine 0.025%) released in 2018
      1. Marketed as OTC to reduce Eye Redness
      2. No proof that it is more effective than OTC ocular Decongestants (e.g. visine) and more expensive
      3. Evaluate Eye Redness for underlying cause instead
      4. (2018) presc lett 25(6): 35 [PubMed]

III. Mechanism

  1. Decrease Aqueous Humor production

IV. Drug Interactions

V. Adverse Effects

  1. Eye itching

VI. Efficacy

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Cost: Medications

apraclonidine (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
APRACLONIDINE HCL 0.5% DROPS Generic $10.86 per ml
brimonidine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
BRIMONIDINE 0.2% EYE DROP Generic $0.76 per ml
BRIMONIDINE TARTRATE 0.15% DRP Generic $19.56 per ml
alphagan (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
ALPHAGAN P 0.1% DROPS $25.67 per ml
ALPHAGAN P 0.15% EYE DROPS Generic $19.56 per ml
mirvaso (on 4/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
MIRVASO 0.33% GEL $14.01 per gram
MIRVASO 0.33% GEL PUMP $13.77 per gram