II. Preparations
- Apraclonidine (Lopidine)
- Brimonidine (Alphagan)
- Available as combination with Brinzolamide (Simbrinza)
- Mirvaso (Brimonidine gel)
- Indicated for Eye Redness due to Rosacea
- Lumify (OTC Brimonidine 0.025%) released in 2018
- Marketed as OTC to reduce Eye Redness
- No proof that it is more effective than OTC ocular Decongestants (e.g. visine) and more expensive
- Evaluate Eye Redness for underlying cause instead
- (2018) presc lett 25(6): 35 [PubMed]
III. Mechanism
- Decrease Aqueous Humor production
IV. Drug Interactions
V. Adverse Effects
- Eye itching
VI. Efficacy
- Less effective than Intraocular Beta Blocker and Intraocular Prostaglandin
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| apraclonidine (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| APRACLONIDINE HCL 0.5% DROPS | Generic | $10.86 per ml |
| brimonidine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| BRIMONIDINE 0.2% EYE DROP | Generic | $0.76 per ml |
| BRIMONIDINE TARTRATE 0.15% DRP | Generic | $19.56 per ml |
| alphagan (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ALPHAGAN P 0.1% DROPS | $25.67 per ml | |
| ALPHAGAN P 0.15% EYE DROPS | Generic | $19.56 per ml |
| mirvaso (on 4/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| MIRVASO 0.33% GEL | $14.01 per gram | |
| MIRVASO 0.33% GEL PUMP | $13.77 per gram | |
