II. Pathophysiology

  1. Agent
    1. Trichothecene Mycotoxins
      1. Produced by filamentous fungi (molds)
    2. Inactivation
      1. Extremely stable in heat and UV light
      2. Destruction requires heating 1500 F for 30 minutes
      3. Brief exposure to sodium Hypochlorite inactivates
  2. Transmission
    1. Used as aerosolized Biological Weapon
      1. Laos, Kampuchea, Afghanistan in late 1970's
    2. Aerosol: "yellow rain" drops of yellow fluid

III. Symptoms and signs

  1. Skin
    1. Local pain
    2. Pruritus
    3. Skin redness
    4. Vesicles
    5. Skin necrosis and sloughing
  2. Respiratory
    1. Nose and throat pain
    2. Nasal Discharge
    3. Itching and sneezing
    4. Cough
    5. Dyspnea
    6. Wheezing
    7. Chest Pain
    8. Hemoptysis
  3. Severe systemic
    1. Prostration
    2. Weakness
    3. Ataxia
    4. Collapse
    5. Shock
    6. Death

IV. Differential Diagnosis

V. Management

  1. Activated Charcoal for ingestion

VI. Prevention

  1. No Vaccine or antitoxin available
  2. Decontamination

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Ontology: T-2 Toxin (C0039185)

Definition (CSP) potent mycotoxin produced in feedstuffs by some Fusarium species.
Definition (MSH) A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.
Concepts Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D013605
SnomedCT 39979007
English Fusariotoxin, Fusaritoxin, T 2 Toxin, T-2 Toxin, T2 Toxin, Toxin, T-2, Toxin, T2, Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-, T AA TOXIN 02, T-2 Toxin [Chemical/Ingredient], t 2 toxins, t-2 toxin, t2 mycotoxin, T-2 fungal toxin, T-2 toxin, T-2 fungal toxin (substance), T2 toxin, Mycotoxin T2
French Toxine T-2, Toxine T2, Fusariotoxine T-2, Mycotoxine T-2
Swedish T-2-toxin
Czech T-2 toxin
Finnish T-2-toksiini
Italian Tossina T2, Fusariotossina, Tossina T-2
German T AA TOXIN 02, Fusaritoxin, T-2-Toxin
Polish Toksyna-2
Japanese フザリトキシン, T-2トキシン
Spanish toxina T-2, toxina fúngica T-2 (sustancia), toxina fúngica T-2, micotoxina T-2 (sustancia), micotoxina T-2, Fusartoxina, Toxina T-2
Portuguese Fusaritoxina, Toxina T-2

Ontology: Trichothecenes (C0040952)

Definition (MSH) Usually 12,13-epoxytrichothecenes, produced by Fusaria, Stachybotrys, Trichoderma and other fungi, and some higher plants. They may contaminate food or feed grains, induce emesis and hemorrhage in lungs and brain, and damage bone marrow due to protein and DNA synthesis inhibition.
Concepts Biologically Active Substance (T123) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D014255
SnomedCT 693002
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English Trichothecenes, Trichothecenes [Chemical/Ingredient], trichothecene, trichothecenes, Trichothecene, Fusarium toxins, Trichothecenes (substance), Fusarium toxins, NOS, Trichothecenes, NOS
Czech trichotheceny
Finnish Trikotekeenit
Japanese トリコテセンエポキシド, トリコテセン, エポキシトリコテセン
Swedish Trikotecener
Polish Trichoteceny
Spanish toxina de fusario, tricotecenos (sustancia), tricotecenos, Tricotecenos
French Trichothécènes
German Trichothecene
Italian Tricoteceni
Portuguese Tricotecenos