Auralgan

Aka: Auralgan, Benzocaine with Antipyrine, U-polycosanol 410, Aurodex

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II. Background

  1. In U.S., FDA forced manufacturers to stop producing Auralgan, Aurodex, A/B Otic...
    1. FDA cited that these agents were unapproved and without evidence of benefit or safety
    2. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm453348.htm

III. Indications

  1. Otalgia

IV. Adverse Effects: Benzocaine related (in Aurodex)

  1. Contact Dermatitis
  2. Methemoglobinemia

V. Precautions

  1. Risk of Methemoglobinemia
    1. Not recommended in age under 2 years
    2. Given lack of topical alternatives, age limit handicaps the Acute Otitis Media Observation protocol
  2. Avoid overuse and stop if topical reaction
    1. Benzocaine (in Aurodex) is a common cause of Contact Dermatitis
  3. Avoid "new" Auralgan containing U-polycosanol 410 (uproven benefit)
    1. Costs $150 instead of old generic version price of $2
    2. Write to allow pharmacist to substitute with Generic Drug (either Aurodex or Benzocaine with Antipyrine)

VI. Dosing

  1. Use 2-4 drops three to four times daily

VII. Reference

  1. (2014) Presc lett 21(6): 36
  2. (2008) Presc Lett 15(5): 26

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Related Studies

Ontology: Auralgan (C0052662)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C061943
English Auralgan, Auralgan (obsolete), Destin brand of acetic acid, benzocaine, glycerol, phenazone, polycosanol drug combination, auralgan
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Antipyrine 54 MG/ML / Benzocaine 14 MG/ML Otic Solution [Auralgan] (C0717202)

Concepts Clinical Drug (T200)
English Auralgan, 54 mg-14 mg/ml otic solution, Antipyrine 54 MG/ML / Benzocaine 14 MG/ML Otic Solution [Auralgan], ANTIPYRINE 54 MG / BENZOCAINE 14 MG / GLYCERIN 1 CC AURICULAR (OTIC) SOLUTION [AURALGAN], Auralgan 54mg-14mg/ml Otic Solution, Auralgan, 54 mg-14 mg/mL otic solution, Auralgan, otic solution, Auralgan (obsolete), 54 mg-14 mg/mL otic solution, Auralgan Otic Solution, Auralgan (antipyrine 54 MG/ML / benzocaine 14 MG/ML) Otic Solution, Auralgan (antipyrine 5.4 % / benzocaine 1.4 % ) Otic Solution, Antipyrine/Benzocaine 54 MG/ML-14 MG/ML Otic Solution [AURALGAN]
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Aurodex (C0718738)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Aurodex, aurodex
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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