Allergic Triad

Aka: Allergic Triad, Aspirin Induced Asthma, Aspirin Allergy

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II. Definition

  1. Allergic constellation centered around Aspirin Allergy

III. Associated Conditions

  1. Aspirin-induced Asthma
  2. Rhinorrhea
  3. Nasal Polyps
  4. Chronic Sinusitis
  5. Conjunctival edema

IV. Course

  1. Onset as perennial Vasomotor Rhinitis
  2. Develops into hyperplastic Rhinosinusitis, Nasal Polyps

V. Causes

  1. Aspirin
  2. Cross-reactivity with NSAIDs
    1. Indomethacin
    2. Naproxen
    3. Ibuprofen
    4. Fenoprofen
    5. Mefenamic acid
    6. Phenylbutazone

VI. Management

  1. Avoid Aspirin and causative NSAIDs above
  2. Use safe alternative Analgesics instead
    1. Salsalate
    2. Acetaminophen
  3. Treat Aspirin-induced Asthma
    1. Leukotriene modifiers (e.g. Sinulair)

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