II. Definition
- Allergic constellation centered around Aspirin Allergy
III. Associated Conditions
- Aspirin-induced Asthma
- Rhinorrhea
- Nasal Polyps
- Chronic Sinusitis
- Conjunctival edema
IV. Course
- Onset as perennial Vasomotor Rhinitis
- Develops into hyperplastic Rhinosinusitis, Nasal Polyps
V. Causes
- Aspirin
- Cross-reactivity with NSAIDs
- Indomethacin
- Naproxen
- Ibuprofen
- Fenoprofen
- Mefenamic acid
- Phenylbutazone
VI. Management
- Avoid Aspirin and causative NSAIDs above
- Use safe alternative Analgesics instead
- Salsalate
- Acetaminophen
- Treat Aspirin-induced Asthma
- Leukotriene modifiers (e.g. Sinulair)
