Benign Premature Thelarche

Aka: Benign Premature Thelarche, Premature Thelarche

II. Epidemiology

  1. Onset as early as age 18 months

III. Pathophysiology

  1. Benign self-limited cause of Precocious Puberty

IV. Exam

  1. Examine with girl lying down
  2. Identify if Breast glandular tissue beneath areola

V. Signs

  1. Early Breast development (not to mature Breast contour)
  2. Isolated glandular Breast tissue on palpation
  3. No other signs of Puberty
  4. Normal prepubertal growth rate

VI. Differential Diagnosis

  1. Lipomastia
    1. Fatty Breast tissue in obese girls

VII. Imaging

  1. Bone Age consistent Chronological age
  2. Ovarian Ultrasound normal

VIII. Labs

  1. Serum Gonadotropin levels normal
  2. Serum Estradiol normal

IX. Management

  1. Reassurance
  2. Do not biopsy Breast
    1. Biopsy results in partial Mastectomy
    2. Further Breast development abnormal post-biopsy

X. Course

  1. Spontaneous resolution

XI. References

  1. Klein (2017) Am Fam Physician 96(9): 590-99 [PubMed]

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Related Studies

Ontology: Premature development of the breasts (C0425772)

Definition (NCI) Isolated breast development prior to the normal age of pubertal onset in females.(NICHD)
Concepts Finding (T033)
ICD10 E30.8
SnomedCT 102889008, 190577006
English Premature thelarche, Premature developmnt of breast, precocious breast development (symptom), premature thelarche, premature thelarche (diagnosis), precocious breast development, precocious thelarche, premature breast development, Premature breast development, Premature thelarche (disorder), Premature Thelarche, Precocious breast development, Precocious thelarche, Premature development of the breasts, Premature breast development at puberty, Premature development of the breasts (finding), precocious; thelarche, premature; thelarche, thelarche; precocious, thelarche; premature
Dutch vroegtijdige thelarche, prematuur; thelarche, thelarche; prematuur, thelarche; vroegtijdigheid, vroegtijdigheid; thelarche
French Thélarche précoce
German vorzeitige Thelarche
Italian Telarca prematuro
Portuguese Telarca prematura
Spanish Telarquia prematura, desarrollo mamario prematuro, desarrollo prematuro de los senos, desarrollo mamario de la pubertad precoz, desarrollo prematuro de las mamas (hallazgo), telarca prematura (hallazgo), desarrollo prematuro de las mamas, telarca prematura, desarrollo mamario de la pubertad prematuro, telarca precoz
Japanese 早発乳房発育開始, ｿｳﾊﾂﾆｭｳﾎﾞｳﾊﾂｲｸｶｲｼ
Czech Předčasná telarché
Hungarian Korai thelarche
Derived from the NIH UMLS (Unified Medical Language System)

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