II. Embryology

  1. Thyroid Gland develops from Tongue root (foramen cecum)
  2. Formed by 5th-6th week of development

III. Anatomy

  1. Images
    1. ThyroidAnterior.gif
  2. Normal Adult Thyroid weighs 20-25g
  3. Components
    1. Two Lateral lobes
    2. Isthmus centrally connects the lobes
  4. Near structures
    1. Recurrent laryngeal nerve
    2. Parathyroid Glands

IV. Physiology

  1. Images
    1. thyroidHormoneSynthesis.png
  2. Stressors stimulate increased Thyroid function
    1. Puberty
    2. Pregnancy
    3. Physiologic stress
  3. Hypothalamus
    1. Thyrotropin Releasing Hormone (TRH) released
    2. TRH passes down pituitary stalk to pituitary
  4. Anterior Pituitary
    1. Thyroid Stimulating Hormone (TSH) released
    2. TSH passes into circulation to Thyroid
  5. Thyroid
    1. Iodine is absorbed from circulation (increased by TSH)
    2. Thyroglobulin is produced, bound to tyrosine molecules and stored within Thyroid follicles
    3. TSH stimulates synthesis of T4 and T3 from tyrosine bound to Thyroglobulin
    4. Thyroxine or Tetraiodothyronine (T4) released into circulation
    5. Triiodthyronine (T3) is also 20-30% produced in the Thyroid (remainder is peripheral conversion of T4)
  6. Peripheral Tissues
    1. Triiodothyronine (T3) produced from T4 deiodination
  7. Circulation
    1. Only unbound Thyroid Hormones (Free T4 or T3) are metabolically active
    2. Thyroid Binding Globulin (TBG) binds T4 and T3
      1. T4 is 99.96% protein bound in serum (<1% is Free T4, the active form)
      2. T3 is 99.7% protein bound in serum
    3. T4 and T3 stimulate all metabolic processes
      1. T3 is several times more potent than T4
  8. Effects of Thyroid Hormone
    1. Triiodthyronine (T3) promotes DNA transcription resulting in RNA translation to enzymes and protein synthesis
    2. Peripheral tissue oxygen utilization and basal metabolic rate increased
    3. Positive chronotropic and ionotropic cardiovascular effects, with secondary increased Cardiac Output
    4. Decreases Systemic Vascular Resistance via arteriole dilation
    5. When Thyroid Hormone is in excess (e.g. Thyroid Storm), high output Heart Failure may result
  9. Feedback Loop
    1. Increased T4 and T3 levels suppress TRH and TSH

V. Pathophysiology

VI. References

  1. Mason, Herbert and Swadron in Herbert (2019) EM:Rap C3 3(11):1-10
  2. Goldberg (2014) Physiology, Medmaster, Miami, p. 136-8

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Related Studies

Ontology: Diiodotyrosine (C0012344)

Definition (MSH) A product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (THYROXINE and TRIIODOTHYRONINE).
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D004105
SnomedCT 80393001
English Acid, Iodogorgoic, Diiodotyrosine, Iodogorgoic Acid, Tyrosine, 3,5-diiodo-, Diiodotyrosine [Chemical/Ingredient], diiodotyrosine, Diiodotyrosine (substance)
Swedish Dijodtyrosin
Czech dijodtyrosin
Finnish Dijodityrosiini
French DIT (Di-IodoTyrosine), Di-iodotyrosine, Diiodotyrosine
Russian DIIODTIROZIN, ДИИОДТИРОЗИН
Japanese ジヨードチロシン, ヨードゴルゴ酸
Italian Acido iodogorgoico, Diiodotirosina
Polish Kwas jodogorgowy, Dwujodotyrozyna, Dijodotyrozyna, DIT
Norwegian Dijodotyrosin
Portuguese Di-Iodotirosina, Ácido Iodogorgoico
Spanish diyodotirosina (sustancia), diyodotirosina, Diyodotirosina, Ácido Yodogorgoico
German Diiodtyrosin, Iodgorgosäure

Ontology: Monoiodotyrosine (C0021996)

Definition (MSH) A product from the iodination of tyrosine. In the biosynthesis of thyroid hormones (THYROXINE and TRIIODOTHYRONINE), tyrosine is first iodized to monoiodotyrosine.
Definition (CSP) product from the iodination of tyrosine; in the biosynthesis of thyroid hormones, tyrosine is first iodized to monoiodotyrosine.
Concepts Biologically Active Substance (T123) , Amino Acid, Peptide, or Protein (T116)
MSH D007470
SnomedCT 91166002
English Iodotyrosine, iodotyrosine, L-Tyrosine, iodo-, Monoiodotyrosine [Chemical/Ingredient], Monoiodotyrosine, Monoiodotyrosine (substance)
Swedish Jodtyrosin
Czech monojodtyrosin
Finnish Monojodotyrosiini
French Mono-iodotyrosine, Monoiodotyrosine, MIT (Mono-Iodotyrosine), Iodotyrosine
Russian IODTIROZIN, MONOIODTIROZIN, ИОДТИРОЗИН, МОНОИОДТИРОЗИН
Japanese モノヨードチロシン, ヨードチロシン
Italian Iodotirosina, Monoiodotirosina
Polish Monojodotyrozyna, MIT, Jodotyrozyna
Norwegian Monojodotyrosin, MIT
Spanish monoyodotirosina (sustancia), monoyodotirosina, Monoyodotirosina, Yodotirosina
German Iodtyrosin, Monojodtyrosin
Portuguese Iodotirosina, Monoiodotirosina

Ontology: Thyroglobulin (C0040123)

Definition (NCI) A glycoprotein hormone that is synthesized by the thyroid follicular cell and is incorporated, by peptide bonds, with thyroid hormones (T3 and T4). Thyroid hormone release occurs when T3 and T4 are enzymatically split from thyroglobulin. Thyroglobulin levels serve as a tumor marker for monitoring the status of differentiated thyroid carcinomas.
Definition (NCI) Expressed in thyroid gland (8.7-kb mRNA), 37-exon 300-kb human TG Gene (Type-B Carboxylesterase/Lipase Family) encodes 2768-aa 305-kDa (precursor) Thyroglobulin, a sulfated homodimeric secreted (follicular) glycoprotein containing 11 thyroglobulin type-I domains and precursor of iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4). Free T4 and T3 hormones are released from hydrolyzed Thyroglobulin. TG defects cause goiter.
Definition (NCI_NCI-GLOSS) The form that thyroid hormone takes when stored in the cells of the thyroid. If the thyroid has been removed, thyroglobulin should not show up on a blood test. Doctors measure thyroglobulin level in blood to detect thyroid cancer cells that remain in the body after treatment.
Definition (CSP) intracellular iodoglycoprotein precursor of thyroxine and triiodothyronine.
Concepts Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) , Hormone (T125)
MSH D013954
SnomedCT 23959001, 34599009
LNC LP14697-4, MTHU005047
English Thyroglobulin, Thyroglobulins, thyroid preparations thyroglobulin (discontinued), thyroglobulin (discontinued) (medication), thyroglobulin (discontinued), Thyroglobulin [Chemical/Ingredient], tg thyroglobulin, Thyroglobulin preparation, TG - Thyroglobulin, Thyroglobulin (substance), Thyroglobulin preparation (product), thyroglobulin, Thyroglobulin preparation (substance), TG, THYROGLOBULIN
Swedish Tyreoglubulin
Czech tyreoglobulin, thyreoglobulin
Finnish Tyreoglobuliini
Russian TIREOGLOBULIN, ТИРЕОГЛОБУЛИН
Spanish preparado con tiroglobulina (producto), tiroglobulina (producto), preparado con tiroglobulina, preparado de tiroglobulina (producto), preparado de tiroglobulina (sustancia), preparado de tiroglobulina, tiroglobulina (sustancia), tiroglobulina, Tiroglobulina
Croatian TIREOGLOBULIN
Polish Tyreoglobulina
Portuguese Tiroglobulina, Tireoglobulina
French Thyroglobuline
German Thyreoglobulin
Italian Tiroglobulina

Ontology: Thyroid Diseases (C0040128)

Definition (MEDLINEPLUS)

Your thyroid is a butterfly-shaped gland in your neck, just above your collarbone. It is one of your endocrine glands, which make hormones. Thyroid hormones control the rate of many activities in your body. These include how fast you burn calories and how fast your heart beats. All of these activities are your body's metabolism.

If your thyroid gland is not active enough, it is called hypothyroidism. It can make you gain weight, feel fatigued, and have difficulty dealing with cold temperatures.

If your thyroid is too active, it makes more thyroid hormones than your body needs. That condition is called hyperthyroidism. Too much thyroid hormone can make you lose weight, speed up your heart rate, and make you very sensitive to heat.

There are many causes for both conditions. Treatment involves trying to reset your body's metabolism to a normal rate.

The thyroid gland can also develop cancer.

Dept. of Health and Human Services Office on Women's Health

Definition (NCI) A non-neoplastic or neoplastic disorder that affects the thyroid gland. Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, follicular adenoma, and carcinoma.
Definition (CSP) condition in which there is a deviation from or interruption of the normal structure or function of the thyroid gland, which is a highly vascular endocrine gland that produces the thyroid hormones which are concerned in regulating the metabolic rate of the body.
Definition (MSH) Pathological processes involving the THYROID GLAND.
Concepts Disease or Syndrome (T047)
MSH D013959
ICD9 246.9, 240-246.99
ICD10 E00-E07.9 , E07.9, E00-E07
SnomedCT 14304000, 190311002, 190232008, 191036006, 154649009
LNC LA17778-4, LA15157-3
English Disease, Thyroid, Diseases, Thyroid, Thyroid Diseases, Unspecified disorder of thyroid, THYROID DISORDER, Disorders of thyroid gland, Thyroid disorder NOS, Disorder of thyroid, unspecified, THYROID DIS, Disease of thyroid gland, thyroid disorder, thyroid disorder (diagnosis), Thyroid gland disorders, Disorder thyroid, Disorder of thyroid NOS, Thyroid disorders, Thyroid Diseases [Disease/Finding], thyroid gland disease, thyroid gland diseases, abnormal thyroid, diseases of the thyroid gland, thyroid disease, thyroid diseases, thyroid gland disorder, thyroid disorders, thyroid abnormal, thyroid gland disorders, Disorders of thyroid gland (E00-E07), Thyroid disorder NOS (disorder), Thyroid gland--Diseases, Diseases of the thyroid gland, Thyroid Disease, Thyroid disease, Thyroid disorder, disease (or disorder); thyroid, thyroid; disorder, Disease of thyroid gland, NOS, Disorder of thyroid gland, NOS, Thyroid disorder, NOS, Disorder of thyroid gland, Disease of thyroid gland (disorder), Disorder of thyroid gland (disorder), Thyroid Disorders, Thyroid Gland Diseases, Thyroid Gland Disease, Thyroid Gland Disorders, Thyroid Gland Disorder, DISORDERS OF THYROID GLAND
Italian Patologia della tiroide, Patologie della ghiandola tiroidea, Disturbo della tiroide, Patologia della tiroide NAS, Disturbo non specificato della tiroide, Malattie tiroidee
Dutch schildklieraandoening NAO, aandoening schildklier, niet-gespecificeerde schildklieraandoening, aandoening; schildklier, schildklier; aandoening, Schildklieraandoening, niet gespecificeerd, schildklieraandoeningen, thyroïdaandoening, Schildklieraandoening, Schildklierziekte, Schildklierziekten, Ziekte, schildklier-
French Trouble de la thyroïde non précisé, Trouble thyroïdien SAI, TROUBLE THYROIDIEN, Trouble thyroïdien, Troubles de la glande thyroïde, Maladies thyroidiennes, Maladies de la thyroïde
German unspezifische Funktionsstoerung der Schilddruese, Erkrankungen der Schilddruese NNB, Erkrankung der Schilddruese, Krankheit der Schilddruese, nicht naeher bezeichnet, SCHILDDRUESENSTOERUNG, Erkrankungen der Schilddruese, Schilddruesenerkrankung, Schilddrüsenkrankheiten
Portuguese Doença da tiroideia NE, Afecção NE da tiroideia, Afecção da tiroideia, ALTERACAO TIROIDEIA, Doenças da Glândula Tireoide, Doenças da Tireoide, Anomalia da tireóide, Doenças da tiroideia
Spanish Trastorno no especificado del tiroides, Trastorno de tiroides NEOM, enfermedad de la glándula tiroides (trastorno), TIROIDES, TRASTORNO, trastorno tiroideo, SAI (trastorno), trastorno tiroideo, SAI, Enfermedades de la Glándula Tiroides, Enfermedades Tiroideas, trastorno tiroideo, Trastorno de tiroides, Trastornos de la glándula tiroides, trastorno de la glándula tiroides, trastorno de la glándula tiroides (trastorno), enfermedad de la glándula tiroides, Enfermedades de la Tiroides
Japanese 甲状腺障害, 甲状腺障害NOS, 詳細不明の甲状腺障害, コウジョウセンショウガイNOS, コウジョウセンショウガイ, ショウサイフメイノコウジョウセンショウガイ
Swedish Sköldkörtelsjukdomar
Finnish Kilpirauhasen sairaudet
Russian SHCHITOVIDNOI ZHELEZY BOLEZNI, ЩИТОВИДНОЙ ЖЕЛЕЗЫ БОЛЕЗНИ
Czech Porucha štítné žlázy, Porucha štítné žlázy NOS, Poruchy štítné žlázy, Blíže neurčená porucha štítné žlázy, thyreoidea - nemoci, nemoci tyreoidey, tyreoidea - nemoci, nemoci štítné žlázy
Korean 상세불명의 갑상샘의 장애
Croatian TIREOIDNE BOLESTI, BOLESTI ŠTITNJAČE, TIROIDNE BOLESTI
Polish Choroby tarczycy
Hungarian Pajzsmirigy nem meghatározott betegsége, Pajzsmirigy betegségek, Pajzsmirigy betegség k.m.n., Pajzsmirigy betegség
Norwegian Sykdommer i skjoldbruskkjertelen, Skjoldbruskkjertelsykdommer

Ontology: Thyroid Gland (C0040132)

Definition (FMA) Lobular organ the parenchyma of which consists of ductless, glandular follicles filled with colloid. Examples: thyroid gland proper, accessory thyroid gland, lingual thyroid gland.
Definition (MSHCZE) Žláza s vnitřní sekrecí tvořená dvěma laloky spojenými úzkým můstkem (isthmem). Je umístěna na krku v oblasti chrupavky štítné. Histologicky je patrná folikulární struktura; v centru folikulů je hlenovitá hmota a jsou zde shromažďovány prekurzory hormonů. Hormony štítné žlázy (thyroxin a trijodthyronin) obsahují jod, který je důležitý pro její funkci. Hormony mají význam pro látkovou výměnu a pro rozvoj mozku v dětství. Jejich tvorba je řízena z předního laloku hypofýzy TSH. Mimo to jsou ve štítné žláze buňky (C-buňky, parafolikulární) produkující hormon kalcitonin, který ovlivňuje hospodaření s vápníkem. Hlavní choroby t. jsou struma, záněty (tyroiditidy), poruchy funkce (hypertyreóza, hypotyreóza), karcinomy. (cit. Velký lékařský slovník online, 2012 http://lekarske.slovniky.cz/ )
Definition (UWDA) Lobular organ the parenchyma of which consists of ductless, glandular follicles filled with colloid. Examples: thyroid gland proper, accessory thyroid gland, lingual thyroid gland.
Definition (NCI_NCI-GLOSS) A gland located beneath the larynx (voice box) that makes thyroid hormone and calcitonin. The thyroid gland helps regulate growth and metabolism.
Definition (NCI) An endocrine gland located at the base of the neck that produces and secretes thyroxine and other hormones. Thyroxine is important for metabolic control.
Definition (NCI_CDISC) An endocrine gland located at the base of the neck that produces and secretes thyroxine and other hormones. Thyroxine is important for metabolic control. (NCI)
Definition (MSH) A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
Definition (CSP) endocrine gland normally situated in the lower part of the front of the neck; secretes, stores and releases the iodine dependent thyroid hormones thyroxine and triiodothyroine which play major endocrine roles in regulating metabolic rate; also secretes thyrocalcitonin.
Concepts Body Part, Organ, or Organ Component (T023)
MSH D013961
SnomedCT 69748006
HL7 THYRD
LNC LP32941-4, LP7636-6, MTHU007792
English Gland, Thyroid, Glands, Thyroid, Thyroid Gland, Thyroid Glands, Thyroid, Thyroids, Glandula thyroidea, thyroid, thyroid glands, thyroids, thyroid gland, THYROID GLAND, Thyroid gland, Thyroid structure, Thyroid structure (body structure), Thyroid gland, NOS, Thyroid, NOS, Head and Neck, Thyroid
French Corps thyroïde, Glande thyroide, Thyroïde
Swedish Sköldkörtel
Czech štítná žláza, tyreoidea, glandula thyreoidea, thyreoidea
Finnish Kilpirauhanen
Russian SHCHITOVIDNAIA ZHELEZA, ЩИТОВИДНАЯ ЖЕЛЕЗА
Japanese 甲状腺
Latvian Vairogdziedzeris
Polish Tarczyca, Gruczoł tarczowy
Croatian ŠTITNA ŽLIJEZDA, ŠTITNJAČA, TIREOIDEJA
Norwegian Skjoldbruskkjertel, Glandula thyreoidea
Portuguese Glândula Tireoide, Tireoide, Glândula Tiroide, Tiroide
Spanish estructura de la glándula tiroides (estructura corporal), estructura de la glándula tiroides, glándula tiroides, Glándula Tiroides
German Glandula thyreoidea, Schilddrüse
Italian Tiroide
Dutch Glandula thyreoidea, Schildklier

Ontology: Thyroid Hormones (C0040135)

Definition (NCI_NCI-GLOSS) A hormone that affects heart rate, blood pressure, body temperature, and weight. Thyroid hormone is made by the thyroid gland and can also be made in the laboratory.
Definition (NCI) Any of several closely related compounds that are produced by the thyroid gland and are active metabolically.
Definition (CSP) any of several closely related compounds that are produced by the thyroid gland and are active metabolically.
Definition (MSH) Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.
Concepts Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D013963
SnomedCT 325311005, 18220004, 61020000
LNC LP31666-8
English Hormones, Thyroid, Thyroid Hormones, Thyroid Hormones [Chemical/Ingredient], thyroid hormone, thyroid hormones, Thyroid hormones, Thyroid hormones (product), Thyroid hormone, Thyroid hormone (substance), Thyroid hormone, NOS, Thyroid hormones (substance), Thyroid Gland Hormone, Thyroid Hormone
Swedish Sköldkörtelhormoner
Czech thyreoidální hormony, tyreoidální hormony
Finnish Kilpirauhashormonit
Russian SHCHITOVIDNOI ZHELEZY GORMONY, TIREOIDNYE GORMONY, ТИРЕОИДНЫЕ ГОРМОНЫ, ЩИТОВИДНОЙ ЖЕЛЕЗЫ ГОРМОНЫ
Croatian TIREOIDNI HORMONI
Polish Hormony tarczycy
Norwegian Skjoldkjertelhormoner, Thyreoideahormoner
Spanish hormonas tiroideas (producto), hormonas tiroideas, Hormonas de la Glándula Tiroides, hormona tiroidea (sustancia), hormona tiroidea, Hormonas Tiroideas
Portuguese Hormônios Tireoideanos, Hormônios Tireoidianos, Hormônios da Glândula Tireoide, Hormônios Tireóideos
French Hormones thyroïdiennes
German Thyreoideahormone, Schilddrüsenhormone
Italian Ormoni della tiroide

Ontology: Thyroxine (C0040165)

Definition (CHV) thyroid hormone
Definition (CHV) thyroid hormone
Definition (CHV) thyroid hormone
Definition (CHV) thyroid hormone
Definition (CHV) thyroid hormone
Definition (CHV) thyroid hormone
Definition (NCI_NCI-GLOSS) A hormone that is made by the thyroid gland and contains iodine. T4 increases the rate of chemical reactions in cells and helps control growth and development. T4 can also be made in the laboratory and is used to treat thyroid disorders.
Definition (NCI) A hormone synthesized and secreted by the thyroid gland containing four iodine atoms and is converted to triiodothyronine (T3) in the body, influencing metabolism and organ function.
Definition (MSH) The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
Definition (CSP) tetraiodothyronine (T4); major hormone elaborated by the thyroid gland follicular cells; increases the rate of cell metabolism, essential for central nervous system maturation, and regulates a number of other functions.
Definition (PDQ) A hormone synthesized and secreted by the thyroid gland containing four iodine atoms and is converted to triiodothyronine (T3) in the body, influencing metabolism and organ function. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=528273&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=528273&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2302" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D013974
SnomedCT 73187006, 38076006
LNC LP145811-8
English 3,5,3',5'-Tetraiodothyronine, L Thyroxine, L-3,5,3',5'-Tetraiodothyronine, L-Thyroxine, Levothyroxine, Thyroxin, Thyroxine, O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine, Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, T4, T4 preparation, T<sub>4</sub> preparation, T<sub>4</sub>, thyroxine, T AAB THYROID HORMONE 004, THROXINE L, Thyroxine [Chemical/Ingredient], l-thyroxine, thyroxine (T4), l thyroxine, LEVOTHYROXINE, T4 Thyroid Hormone, Thyroid Hormone, T4, thyroxin, L-3,5,5'-tetraiodothyronine, levothyroxine, 3,5,3'5' Tetraiodothyronine, Tetraiodothyronine preparation, Thyroxine preparation, Thyroxine product, T4 - Thyroxine, Total thyroxine, TT4 - Total thyroxine, T>4< preparation, T>4<, Tetraiodothyronine preparation (product), Thyroxine (substance), Tetraiodothyronine preparation (substance)
Portuguese L-Tireoxina, Levotireoxina, Tireoxina, Tetraiodotironina, Tireotoxina, Levotiroxina, Tirotoxina, Hormônio T4 da Tireoide, T4, Tiroxina, Hormônio Tireóideo T4
Swedish Tyroxin
Czech thyroxin, hormon T4, tyroxin
Finnish Tyroksiini
French T4 (Hormone thyroïdienne), Lévothyroxine, L-Thyroxine, 3,5,3',5'-Tétraiodothyronine, Hormone thyroïdienne T4, LTX (LévoThyroXine), Tétra-iodothyronine, Tétraiodothyronine, Thyroxine
Russian L-3,5,3',5'-TETRAIODTIRONIN, L-TIROKSIN, TIROKSIN, LEVOTIROKSIN, L-3,5,3',5'-ТЕТРАИОДТИРОНИН, L-ТИРОКСИН, ЛЕВОТИРОКСИН, ТИРОКСИН
Japanese サイロキシン, テトラヨードチロニン, レボチロキシンナトリウム水和物, L-チロキシン, チラージンS, レボチロキシンナトリウム, チラーヂンS, フリーT4, チロキシン, レボサイロキシン, レボチロキシン, L-3,5,3',5'-テトラヨードチロニン
Spanish T4, preparado con tetrayodotironina (producto), tetrayodotironina, preparado de tiroxina, tetrayodotironina (producto), preparado con tetrayodotironina, 3, 5, 3'5' tetrayodotironina, preparado de T>4, preparado de tetrayodotironina (producto), preparado de tetrayodotironina (sustancia), preparado de tetrayodotironina, tiroxina (sustancia), tiroxina, Tiroxina, Hormona Tiroidea T4, Levotiroxina, Tiroxina-L
German T AAB SCHILDDRÜSENHORMON 004, THYROXIN A L, L-Thyroxin, Laevothyroxin, Levothyroxin, Thyroxin, T4-Schilddrüsenhormon
Croatian TIROKSIN
Polish L-tyroksyna, Tyroksyna, Sól sodowa lewotyroksyny, Lewotyroksyna
Norwegian O-(4-hydroksi-3,5-dijodfenyl)-3,5-dijodtyrosin, Thyroksin, L-3,5,3',5'-tetrajodtyronin, T4 thyreoideahormon, Levotyroksin, O-(4-hydroksi-3,5-dijodfenyl) 3,5-dijodo-L-tyrosin, Tyroksin, 3,5,3',5'-tetrajodtyronin, L-tyroksin
Italian Tiroxina

Ontology: Triiodothyronine (C0041014)

Definition (NCI) A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity.
Definition (NCI) A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
Definition (NCI_NCI-GLOSS) A thyroid hormone.
Definition (MSH) A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
Definition (CSP) one of the thyroid hormones; an organic iodine containing compound secreted in small amounts by the thyroid gland; most circulating triiodothyroinine is produced by the deiodination of thyroxine in the peripheral tissues.
Definition (PDQ) A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=470233&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=470233&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C907" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D014284
SnomedCT 61275002, 350358003, 74495008, 36437009
CPT 1011720
LNC LP15922-5, MTHU003701
English Liothyronine, Triiodothyronine, triiodothyronine, L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, 3,3',5-triiodo-L-thyronine, T3, T<sub>3</sub>, L-triiodothyronine preparation, T>3< preparation, T<sub>3</sub> preparation, T3 preparation, therapeutic triiodothyronine, L-Triiodothyronine, T AAA THYROID HORMONE 003, Triiodothyronine [Chemical/Ingredient], t3 thyroid hormone, t3, LIOTHYRONINE, T3 Thyroid Hormone, Thyroid Hormone, T3, Triiodothyronine preparation, Triiodothyronine preparation (product), Triiodothyronine T3, T-3, liothyronine, 3,5,3' Triiodothyronine, T3 - Liothyronine, Tri-iodothyronine product, T3 - Triiodothyronine, Total triiodothyronine, T>3<, Liothyronine (product), Triiodothyronine (substance), Liothyronine (substance), Triiodothyronine preparation (substance), Therapeutic T3
Swedish Trijodtyronin
Spanish liotironina, liotironina (producto), preparado con triyodotironina, tri-iodotironina, producto (producto), tri-iodotironina, producto, preparado de T3, preparado de T<sub>3</sub>, preparado con T>3<, preparado de L-triyodotironina, preparado con triyodotironina (producto), preparado con T3, preparado con T<sub>3</sub>, T3, 3, 5, 3' triyodotironina, preparado de T>3<, preparado de triyodotironina (producto), preparado de triyodotironina (sustancia), preparado de triyodotironina, tri-iodotironina, producto (sustancia), triyodotironina (sustancia), triyodotironina, Triyodotironina, Hormona Tiroidea T3, Liotironina
Czech hormon T3, trijodthyronin
Finnish Trijodotyroniini
French T3 (Hormone thyroïdienne), Tri-iodothyronine, Hormone thyroïdienne T3, Triiodothyronine, 3,5,3'-triiodothyronine, Liothyronine
Russian TRIIODTIRONIN, LIOTIRONIN, ЛИОТИРОНИН, ТРИИОДТИРОНИН
Japanese リオチロニン, フリーT3, リオサイロニン, トリヨードチロニン, トリヨードサイロニン, L-トリヨードチロニン
German T AAA SCHILDDRÜSENHORMON 003, Liothyronin, Triiodthyronin, T3-Schilddrüsenhormon
Croatian TRIJODTIRONIN
Polish Trójjodotyronina, T3, Trijodotyronina
Norwegian Liotyronine, Trijodtyronin, T3 thyreoideahormon
Portuguese Tri-Iodotironina, Hormônio T3 da Tireoide, T3, Hormônio Tireóideo T3, Liotironina
Italian Triiodotironina