Tazarotene

Aka: Tazarotene, Tazorac

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II. Indications

  1. Psoriasis
    1. Primary use
  2. Acne Vulgaris
    1. Other Comedolytics are better tolerated (Retin A, Adapalene)

III. Mechanism

  1. Retinoid
  2. Suppresses epidermal thickening, Scaling

IV. Preparations

  1. Cream 0.05%, 0.1%
  2. Gel 0.05%, 0.1%

V. Dosing

  1. Applied each day
  2. Quick onset of benefit
  3. Start at 0.05% gel, may advance to 0.1% gel

VI. Efficacy

  1. Under 50% have moderate to marked benefit
  2. Best used in combination with topicals
  3. Benefit may last for several weeks after stopping

VII. Adverse Effects

  1. Local irritation is common
    1. Erythema in almost everyone
    2. Peeling and dryness
    3. Pruritus, stinging and burning
    4. Not tolerated by 10% of patients
  2. Risk of Koebner Reaction
    1. Results in larger area Psoriasis
    2. Apply strictly to lesion

VIII. Safety

  1. Pregnancy Category X

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Cost: Medications

tazorac (on 1/1/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
TAZORAC 0.05% CREAM $10.89 per gram
TAZORAC 0.05% GEL $10.89 per gram
TAZORAC 0.1% CREAM $11.63 per gram
TAZORAC 0.1% GEL $11.56 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: tazarotene (C0288792)

Definition (NCI_NCI-GLOSS) A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Tazarotene is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Tazarotene is a type of synthetic retinoid.
Definition (NCI) A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C086827
SnomedCT 332218002, 108906007, 386935009
English 3-Pyridinecarboxylic acid, 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-, ethyl ester, ethyl 6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate, tazarotene, Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate, 6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester, retinoids tazarotene, tazarotene (medication), tazarotene [Chemical/Ingredient], TAZAROTENE, Tazarotene, Tazarotene (product), Tazarotene (substance)
Spanish tazaroteno (producto), tazaroteno (sustancia), tazaroteno
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Tazorac (C0723607)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C086827
English Tazorac, tazorac
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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