Calcipotriene

Aka: Calcipotriene, Donovex

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II. Indication

  1. Psoriasis

III. Dosing

  1. Ointment applied qd-bid

IV. Efficacy

  1. Begin to see benefit in 2 weeks
  2. Maximum benefit in 6-8 weeks
    1. Resolution in 10% of patients
    2. Moderate Improvement in 70% of patients
    3. No Improvement in 20% of patients
  3. Useful adjunct to PUVA

V. Adverse effects

  1. May be irritating, more so in fold areas
  2. Do not use on face
  3. Vitamin D analog - risk of Hypercalcemia
    1. Limit to 100 grams per week

VI. Disadvantages

  1. Expensive ($100 for 2 ounces)

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Cost: Medications

calcipotriene (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CALCIPOTRIENE 0.005% CREAM Generic $2.67 per gram
CALCIPOTRIENE 0.005% OINTMENT Generic $3.57 per gram
CALCIPOTRIENE 0.005% SOLUTION Generic $2.54 per ml
CALCIPOTRIENE-BETAMETH DP OINT Generic $8.92 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: calcipotriene (C0065767)

Definition (NCI) A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C055085
SnomedCT 108910005, 126232005, 395766004
English 9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-triol, 24-cyclopropyl-, (1alpha,3beta,5Z,7E,22E)-, calcipotriol, 1,24(OH)2-22-ene-24-cyclopropyl D3, calcipotriene, calcipotriene (medication), CALCIPOTRIENE, calcipotriene [Chemical/Ingredient], Calcipotriene (product), Calcipotriol, Calcipotriene preparation (product), Calcipotriene preparation, Calcipotriol (substance), Calcipotriene (substance), Calcipotriene preparation (substance), Calcipotriene
Spanish calcipotrieno (producto), calcipotrieno, preparado con calcipotrieno (producto), preparado con calcipotrieno, calcipotrieno (sustancia), calcipotriol (sustancia), calcipotriol, preparado de calcipotrieno (producto), preparado de calcipotrieno (sustancia), preparado de calcipotrieno
Derived from the NIH UMLS (Unified Medical Language System)

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