Ciclopirox

Aka: Ciclopirox, Loprox, Penlac

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II. Indications

  1. Dermatophyte Infection (Tinea Corporis)
  2. Cutaneous Candidiasis
  3. Tinea Versicolor

III. Preparations

  1. Cutaneous dermatophytes: Ciclopirox olamine 1% (Loprox)
  2. Onychomycosis: Ciclopirox 8% lacquer (Penlac)

IV. Mechanism: Broad-spectrum activity

  1. Antifungal for dermatophytes and yeast
  2. Some antibacterial activity in vitro
    1. Gram Positive Bacteria
    2. Gram Negative Bacteria

V. Efficacy

  1. Tinea Pedis (Loprox)
    1. More effective than OTC Clotrimazole (Lotrimin)
  2. Onychomycosis (Penlac)
    1. NOT recommended
    2. Requires 48 week application
    3. Minimally better than Placebo for cure rates
    4. Partial clearance rates are also poor

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Cost: Medications

ciclopirox (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CICLOPIROX 0.77% CREAM Generic $0.34 per gram
CICLOPIROX 0.77% GEL Generic $1.13 per gram
CICLOPIROX 0.77% TOPICAL SUSP Generic $0.85 per ml
CICLOPIROX 1% SHAMPOO Generic $0.56 per ml
CICLOPIROX 8% SOLUTION Generic $3.03 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ontology: ciclopirox (C0055711)

Definition (NCI) A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C011585
SnomedCT 372854000, 79736009
English ciclopirox, cyclopirox, ciclopirox (medication), CICLOPIROX, ciclopirox [Chemical/Ingredient], Ciclopirox, Ciclopirox (product), Ciclopirox (substance)
Spanish ciclopirox (producto), ciclopirox (sustancia), ciclopirox
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Loprox (C0733447)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C011585
English Loprox, loprox
Derived from the NIH UMLS (Unified Medical Language System)

Ontology: Penlac (C1130459)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C011585
English penlac, Penlac
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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