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Ontology:
ciclopirox
(C0055711)
Definition (NCI)
|
A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C011585
|
SnomedCT |
372854000, 79736009 |
English |
ciclopirox, cyclopirox, ciclopirox (medication), CICLOPIROX, ciclopirox [Chemical/Ingredient], Ciclopirox, Ciclopirox (product), Ciclopirox (substance) |
Spanish |
ciclopirox (producto), ciclopirox (sustancia), ciclopirox |
Ontology:
Loprox
(C0733447)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C011585
|
English |
Loprox, loprox |
Ontology:
Penlac
(C1130459)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C011585
|
English |
penlac, Penlac |