II. Mechanism

  1. Naphthalenemethylamine derivative (similar to Terbinafine)

III. Indications

  1. Refractory cutaneous Tinea Infections (e.g. Tinea Pedis, Tinea Cruris)

IV. Dosing

  1. Apply once daily for 14 days to a 2 cm area surrounding Skin Infection
  2. Note: Unlike other Topical Antifungals, once daily application is sufficient

V. Advantages

  1. Shorter course (2 instead of 4 weeks) than Clotrimazole
  2. More convenient (once daily) than other Topical Antifungals

VI. Disadvantages

  1. Expensive

VII. Efficacy

  1. High tinea cure rates with a 2 week course
  2. At 4-8 weeks, no significant difference in cure as compared with Clotrimazole

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