Nikolsky's Sign

Aka: Nikolsky's Sign, Nikolsky Sign

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II. Indication

  1. Evaluation of Bulla (Blister)

III. Technique

  1. Lateral pressure applied to edge of bulla
  2. Positive test if bulla extends laterally with pressure
    1. Suggests Epidermis detaches from skin

IV. Causes: Positive test

  1. Pemphigus conditions (e.g. Pemphigus Vulgaris)
  2. Stevens-Johnson Syndrome
  3. Toxic Epidermal Necrolysis
  4. Staphylococcus Scalded Skin Syndrome

V. References

  1. Salopek (1997) Br J Dermatol 136(5):762-7 +PMID:9205514 [PubMed]

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Ontology: Nikolsky sign (C0241128)

Concepts Finding (T033)
SnomedCT 441837004
Italian Segno di Nikolsky
Japanese ニコルスキー現象, ﾆｺﾙｽｷｰｹﾞﾝｼｮｳ
Czech Nikolského příznak
English Nikolsky's sign, Nikolsky sign (finding), Nikolsky sign, nikolsky sign, nikolsky's sign
Spanish signo de Nikolsky (hallazgo), signo de Nikolsky, Signo de Nikolsky
Hungarian Nikolsky-tünet
Portuguese Sinal de Nikolsky
Dutch verschijnsel van Nikolsky
French Signe de Nikolsky
German Nikolsky Zeichen
Derived from the NIH UMLS (Unified Medical Language System)

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