II. Definition

  1. Less common, milder and superficial form of Pemphigus

III. Signs

  1. Onset on skin of face in butterfly distribution
  2. May also involve scalp, chest or upper back
  3. Rarely involves Oral Mucosa
  4. Nikolsky's Sign absent

IV. Variants

  1. Pemphigus erythematosus (Senear-Usher Syndrome)
    1. Localized variant of Pemphigus Foliaceus
    2. Associated with Systemic Lupus Erythematosus
    3. Antinuclear Antibody positive
  2. Fogo selvagem
    1. Variant of Pemphigus Foliaceus
    2. Endemic to Brasil and Colombia
    3. Associated with chronic Black Fly exposure
  3. Pemphigus herpetiformis
    1. Pruritic Blister formation
    2. May appear similar to Dermatitis Herpetiformis
  4. Drug-Induced Pemphigus
    1. Associated with Penicillamine and Captopril
    2. Differentiate from Drug-Triggered Pemphigus
      1. Unmasks Pemphigus Vulgaris

V. Labs: Histology

  1. Blister forms just below Stratum Corneum of Epidermis

VI. References

  1. Habif (1996) Clinical Dermatology, Mosby, p. 510
  2. Cotell (2000) Am J Emerg Med 18(3):288-99 [PubMed]

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Related Studies

Ontology: Pemphigus erythematosus (C0263312)

Concepts Disease or Syndrome (T047)
ICD10 L10.4
SnomedCT 36739006
Dutch erythemateuze pemphigus, pemphigus erythematosus, erythematosus; pemphigus, pemphigus; erythematosus, Pemphigus erythematosus
French Pemphigus érythémateux
German Pemphigus erythematoes, Pemphigus erythematosus
Italian Pemfigo eritematoso
Portuguese Pênfigo eritematoso
Spanish Pénfigo eritematoso, pénfigo eritematoso (trastorno), pénfigo eritematoso, síndrome de Senear - Usher
Japanese 紅斑性天疱瘡, コウハンセイテンポウソウ
English pemphigus erythematosus (diagnosis), pemphigus erythematosus, Pemphigus erythematous, Pemphigus erythematosis, Pemphigus erythematosus, Senear-Usher syndrome, Pemphigus erythematosus (disorder), Senear-Usher, Usher-Senear, erythematosus; pemphigus, pemphigus; erythematosus, Pemphigus, erythematosus
Czech Pemphigus erythematosus, Erytematózní pemfigus, pemphigus erythematosus
Korean 홍반성 천포창
Hungarian Pemphigus erythematosis, Pemphigus erythemas, Pemphigus erythematosus

Ontology: Pemphigus Foliaceus (C0263313)

Concepts Disease or Syndrome (T047)
MSH D010392
ICD10 L10.2
SnomedCT 35154004
Dutch pemphigus foliaceus, foliaceus; pemphigus, pemphigus; foliaceus, Pemphigus foliaceus
French Pemphigus foliaceus, Pemphigus foliacé
German Pemphigus blattfoermig, Pemphigus foliaceus
Italian Pemfigo foliaceo, Pemfigo fogliaceo
Portuguese Pênfigo foliáceo
Spanish Pénfigo foliáceo, pénfigo foliáceo (trastorno), pénfigo foliáceo
Japanese 落葉状天疱瘡, ラクヨウジョウテンポウソウ
English pemphigus foliaceus (diagnosis), pemphigus foliaceus, pemphigus foliaceous, Pemphigus foliaceus, Pemphigus foliaceous, PF - Pemphigus foliaceous, Pemphigus foliaceus (disorder), foliaceous; pemphigus, Cazenave, pemphigus; foliaceous, Pemphigus, foliaceus, Foliaceus, Pemphigus, Pemphigus Foliaceus
Czech Pemphigus foliaceus
Korean 낙엽상 천포창
Hungarian Pemphigus foliaceus, foliaceus pemphigus
Norwegian Pemphigus foliaceus

Ontology: Pemphigus and fogo selvagem (C0263314)

Concepts Disease or Syndrome (T047)
MSH C535551
ICD10 L10.3
SnomedCT 200906007, 46459009
English Brazilian pemphigus [fogo selvagem], Brazilian pemphigus foliaceus (diagnosis), fogo selvagem, Endemic pemphigus foliaceus, Pemphigus and fogo selvagem, Brazilian pemphigus, South American pemphigus, wild fire, Brazilian pemphigus (disorder), Amendola's syndrome, Brazilian pemphigus foliaceus, Fogo selvagem, Wildfire pemphigus, Wild fire, Brazilian pemphigus foliaceus (disorder), Brazilian; pemphigus, pemphigus; Brazilian
German Brasilianischer Pemphigus [fogo selvagem]
Korean 브라질 천포창[포고 셀바젬병]
Dutch Braziliaans; pemphigus, pemphigus; Braziliaans, Braziliaanse pemphigus [fogo selvagem]
Spanish fuego salvaje, pénfigo foliáceo brasilero, pénfigo foliáceo brasileño (trastorno), pénfigo foliáceo brasileño, síndrome de Améndola