II. Indications
III. Mechanism: Benign Prostatic Hypertrophy
- Background
- Non-Selective Postsynaptic Alpha Adrenergic Antagonist (Terazosin, Doxazosin, Prazosin)
- Relatively weak antihypertensives, were often used for BPH
- Selective Alpha-1a Antagonist
- Developed for specific Alpha-1a activity with minimal antihypertensive effects
- Non-Selective Postsynaptic Alpha Adrenergic Antagonist (Terazosin, Doxazosin, Prazosin)
- Rapid relaxation of Smooth Muscle tone
- Relieves symptoms of urinary obstruction
- May see full effect within 2 weeks
- Does not effect size of Prostate (unlike Proscar)
IV. Preparations: Selective Alpha-1a Antagonists (Prostate specific agents)
- Precautions
- Still cause Orthostatic Hypotension, fall risk, Head Trauma and Fractures, despite selective nature
- Number needed to harm (NNH): 600 for fall-related hospitalizations, and 1600 for fall-related Fractures
- Welk (2015) BMJ 351:h5398 +PMID:26502947 [PubMed]
- Alfuzosin (Uroxatral, generic)
- Dose: 10 mg once daily
- Contraindicated in moderate to severe liver disease (and Exercise caution in renal disease)
- Silodosin (Rapaflo)
- Dose: 8 mg daily with food (4 mg daily if GFR 30-50 ml/min)
- Contraindicated when GFR <30 ml/min or severe liver disease (Child-Pugh Score 10 or more)
- Tamsulosin (Flomax, generic)
- Dose 0.4 mg orally daily (maximum 0.8 mg/day)
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Related Studies
| tamsulosin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| TAMSULOSIN HCL 0.4 MG CAPSULE | Generic | $0.14 each |
| flomax (on 1/4/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| FLOMAX 0.4 MG CAPSULE | Generic | $0.14 each |
| alfuzosin (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ALFUZOSIN HCL ER 10 MG TABLET | Generic | $0.17 each |
| uroxatral (on 5/18/2016 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| UROXATRAL 10 MG TABLET | Generic | $0.17 each |
| rapaflo (on 2/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| RAPAFLO 4 MG CAPSULE | $7.30 each | |
| RAPAFLO 8 MG CAPSULE | $7.29 each | |
Ontology: tamsulosin (C0257343)
| Definition (NCI_NCI-GLOSS) | A drug used to treat urinary problems caused by an enlarged prostate. Tamsulosin relaxes the muscles of the prostate and bladder, which helps the flow of urine. It is a type of alpha blocker. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C088482 |
| SnomedCT | 108559004, 372509005 |
| LNC | LP171642-4 |
| English | 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide, tamsulosin, 5-((2R)-2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy-benzenesulfonamide, tamsulosin [Chemical/Ingredient], TAMSULOSIN, Tamsulosin, Tamsulosin (product), Tamsulosin (substance) |
| Spanish | tamsulosina (producto), tamsulosina (sustancia), tamsulosina |
Ontology: Flomax (C0662903)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C088482 |
| English | Flomax, Abbott laboratories brand of tamsulosin hydrochloride, flomax |
