II. Mechanism

  1. Peripheral Acting Adrenergic Antagonists block Norepinephrine release from postganglionic nerve terminals

III. Preparations

  1. Reserpine (Serpasil)
  2. Guanethidine (Ismelin)
  3. Guanadrel (Hylorel)

Images: Related links to external sites (from Bing)

Related Studies

Ontology: Guanethidine (C0018318)

Definition (MSH) An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D006145
SnomedCT 387456007, 79305004
English Guanethidine, Octadine, Oktadin, ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine, guanethidine, Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, guanethidines (medication), guanethidines, Octatensine, (2-(Octahydro-1-azocinyl)ethyl)guanidine, Guanethidine [Chemical/Ingredient], Guanethidine (product), Guanethidine (substance), GUANETHIDINE
Swedish Guanetidin
Czech guanethidin
Finnish Guanetidiini
Japanese グアネチジン, 硫酸グアネチジン
Polish Guanetydyna, Ismelina
Spanish guanetidina (producto), guanetidina (sustancia), guanetidina, Guanetidina
French Guanéthidine
German Guanethidin
Italian Guanetidina
Portuguese Guanetidina

Ontology: Reserpine (C0035179)

Definition (NCI) An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble and can penetrate blood-brain barrier. This agent binds and inhibits catecholamine pump on the storage vesicles in central and peripheral adrenergic neurons, thereby inhibiting the uptake of norepinephrine, dopamine serotonin into presynaptic storage vesicles. This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects.
Definition (MSH) An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Definition (CSP) alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D012110
SnomedCT 363523003, 387447004, 78379001
English Reserpine, Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-, (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester, reserpine, reserpine (medication), Reserpine [Chemical/Ingredient], RESERPINE, Reserpine - chemical, Reserpine - chemical (substance), Reserpine (product), Reserpine (substance)
Swedish Reserpin
Czech reserpin
Finnish Reserpiini
Japanese レセルピン
Polish Rezerpina, Serpazyl
Spanish reserpina - sustancia química (sustancia), reserpina - sustancia química, reserpina (producto), reserpina (sustancia), reserpina, Reserpina
French Réserpine
German Reserpin
Italian Reserpina
Portuguese Reserpina

Ontology: guanadrel (C0061938)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C004945
SnomedCT 372820001, 69204002
English (1,4-dioxaspiro(4.5)dec-2-ylmethyl)guanidine, guanadrel, guanadrel [Chemical/Ingredient], Guanadrel, Guanadrel (product), Guanadrel (substance), GUANADREL
Spanish guanadrel (producto), guanadrel (sustancia), guanadrel

Ontology: Ismelin (C0701214)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D006145
English guanethidine sulfate (Ismelin), Ismelin

Ontology: Hylorel (C0720982)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C004945
English Hylorel, Celltech brand of guanadrel sulfate

Ontology: Serpasil (C0729168)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D012110
English Serpasil