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Ontology:
Diazoxide
(C0012022)
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Definition (NCI)
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A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.
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Definition (CSP)
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peripheral vasodilator that reduces blood pressure; diazoxide also has antidiuretic and hypoglycemic effects.
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Definition (MSH)
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A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
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Definition (PDQ)
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A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39290&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39290&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C428" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D003981
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| SnomedCT |
318642007, 325291008, 387328001, 58905004 |
| LNC |
LP14713-9, MTHU001807 |
| English |
Diazoxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide, 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, diazoxide, Diazoxide [cardiovascular use], Diazoxide [endocrine use], diazoxide (medication), Diazoxide [Chemical/Ingredient], diazoxides, Diazoxide [cardiovascular use] (product), Diazoxide [endocrine use] (product), Diazoxide (product), Diazoxide (substance), Diazoxide [cardiovascular use] (substance), Diazoxide [endocrine use] (substance), DIAZOXIDE |
| Swedish |
Diazoxid
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| Czech |
diazoxid
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| Finnish |
Diatsoksidi
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| Russian |
DIAZOKSID, ДИАЗОКСИД |
| Japanese |
ダイアゾキサイド, ジアゾキシド |
| Croatian |
DIAZOKSID
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| Polish |
Diazoksyd
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| Spanish |
diazóxido (uso cardiovascular), diazóxido [uso endocrino], diazóxido (uso cardiovascular) (producto), diazóxido [uso endocrino] (producto), diazóxido (producto), diazóxido (sustancia), diazóxido, Diazóxido |
| French |
Diazoxide
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| German |
Diazoxid
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| Italian |
Diazossido
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| Portuguese |
Diazóxido
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Ontology:
Hydralazine
(C0020223)
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Definition (NCI)
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A phthalazine derivative with antihypertensive effects. Hydralazine exerts its vasodilatory effects through modification of the contractile state of arterial vascular smooth muscle by altering intracellular calcium release, and interfering with smooth muscle cell calcium influx. This agent also causes inhibition of phosphorylation of myosin protein or chelation of trace metals required for smooth muscle contraction, thereby resulting in an increase in heart rate, stroke volume and cardiac output.
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Definition (MSH)
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A direct-acting vasodilator that is used as an antihypertensive agent.
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Definition (CSP)
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direct-acting vasodilator that is used as an antihypertensive.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D006830
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| SnomedCT |
22696000, 387125005 |
| LNC |
LP15169-3, MTHU002558 |
| English |
Apressin, Hydralazine, Hydrallazin, Hydrazinophthalazine, 1(2H)-Phthalazinone, hydrazone, apressin, 1(2H)-Phthalazinone Hydrazone, Hydralazine [Chemical/Ingredient], HYDRALAZINE, hydrALAZINE, hydralazine (medication), hydralazine, Apressinum, Hydralazine (product), Hydralazine (substance) |
| Swedish |
Hydralazin
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| Czech |
hydralazin
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| Finnish |
Hydralatsiini
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| Russian |
APRESSIN, GIDRALAZIN, АПРЕССИН, ГИДРАЛАЗИН |
| Italian |
Apressina, Idrallazina, Idrazinoftalazina, Idralazina |
| Spanish |
Hidralazina, Hidralacina, hidralazina (producto), hidralazina (sustancia), hidralazina |
| Polish |
Hydralazyna
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| Japanese |
ヒドララジン, 塩酸ヒドララジン |
| French |
Hydralazine
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| German |
Hydralazin, Hydrallazin |
| Portuguese |
Hidralazina
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Ontology:
Apresoline
(C0699178)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D006830
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| English |
Apresoline, apresoline, Apressoline |
Ontology:
Hyperstat
(C0699324)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D003981
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| English |
Hyperstat
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Ontology:
Bidil
(C0968130)
| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
C431665
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| English |
Bidil, BiDil |
