II. Epidemiology

  1. Incidence: 75 cases per 1000 live births (up to 1%, or 40,000 per year in U.S.)
  2. Serious causes requiring surgery in first year of life occur in 25% of cases

III. Precautions

  1. Up to 60% of Congenital Heart Disease has a delayed diagnosis

IV. Causes

  1. See Congenital Heart Disease Causes
  2. Ventricular Septal Defects account for 25% of cases
    1. Most common Congenital Heart Disease surgical repair
  3. Secundum-type Atrial Septal Defects (Ostium Secundum) account for 10% of cases

V. Risk Factors

  1. See Newborn History
  2. Maternal Diabetes Mellitus
  3. Family History of Congenital Heart Disease
    1. Maternal history: 5-10% CHD risk
    2. Sibling history: 2-3% CHD risk
  4. Rubella exposure in first trimester (PDA)
  5. Residence at high altitude (PDA)
  6. Systemic Lupus Erythematosus
  7. Maternal medications and substances
    1. Alcohol use during pregnancy
    2. Valproic Acid
    3. Retinoic Acid
    4. Indomethacin exposure

VI. Associated Conditions

VII. Differential Diagnosis

VIII. History: Family

  1. Family History of Congenital Heart Disease
    1. Hypertrophic Cardiomyopathy
    2. Ventricular Septal Defect
    3. Mitral Valve Prolapse
    4. Premature Sudden Cardiac Death
    5. SIDS
  2. Maternal history
    1. Diabetes Mellitus
      1. Associated with transient Hypertrophic Cardiomyopathy, tetralogy, Truncus Arteriosus, double outlet RV
    2. Rubella
      1. Associated with peripheral pulmonary stenosis, Patent Ductus Arteriosus
  3. Maternal drug and medication uses
    1. Alcohol
      1. See Fetal Alcohol Syndrome associations above
    2. Valproate
      1. Associated with Aortic Coarctation, Hypoplastic Left Heart Syndrome
    3. Lithium
      1. Associated with Ebstein Anomaly tricuspid valve
    4. Selective Serotonin Reuptake Inhibitors (SSRI)
      1. Associated in some studies with Ventricular Septal Defect, bicuspid aortic valve
    5. Hydantoin
    6. Trimethadione
    7. Primidone
    8. Carbamazepine
    9. Retinoic Acid
    10. Chemotherapy
    11. Indomethacin

IX. Symptoms

  1. Children at any age
    1. Dyspnea (74%)
    2. Nausea or Vomiting (60%)
    3. Fatigue (56%)
    4. Cough (40%)
  2. Younger children
    1. Poor feeding
  3. Older children
    1. Exercise Induced Syncope or Cyanosis
    2. Decreased Exercise tolerance

X. Signs

  1. Skin Color
    1. Central Cyanosis in Infants (typically out of proportion to respiratory distress)
      1. Cyanotic Congenital Heart Disease
    2. ' Cyanosis that worsens with crying suggests cardiac cause
      1. Cyanosis that improves with crying is suggests pulmonary cause
    3. Skin mottling in infants suggests aortic disorder
      1. Aortic Coarctation
      2. Severe Aortic Stenosis
    4. Pink skin in an infant with findings of CHF
      1. Left to right heart shunt (e.g. large ASD or VSD)
    5. Other skin findings of decreased perfusion
      1. Prolonged Capillary Refill Time
      2. Mottled extremities
      3. Cool distal extremities
  2. Signs of Respiratory distress
    1. Grunting
    2. Tachypnea (may also occur in cardiac lesions with acidosis)
    3. Wheezing
    4. Increased work of breathing and accessory Muscle use
  3. Difficult feeding precedes Congestive Heart Failure
    1. Term infant parameters
      1. Prolonged feeding longer than 40 minutes
      2. Less than 2 ounces per feeding
    2. Distress signs provoked by feeding
      1. Tachypnea
      2. Diaphoresis
      3. Subcostal retraction
    3. Failure to Thrive
      1. Height and Head Circumference may be normal
      2. Weight falls behind
  4. Precordial examination
    1. S3 Gallup Rhythm or thrill (CHF)
    2. Cardiac Murmur
      1. See Pediatric Murmur evaluation
      2. Often the least important of exam
  5. Femoral and Brachial Pulse
    1. Compare both brachial pulses for symmetry
      1. Brachial pulses absent in left sided obstruction
    2. Compare one brachial and one femoral pulse
      1. Femoral Pulses diminish with PDA closure
  6. Other Congestive Heart Failure signs
    1. Hepatomegaly
    2. Edema
  7. Oxygen Saturation in the right hand (pre-ductal)
    1. Hyperoxia testing involves delivering 100% oxygen for 10 minutes
    2. Pulmonary cause related Cyanosis
      1. Supplemental Oxygen 100% increases O2 Sat >95% or
      2. Supplemental Oxygen 100% improves O2 Sat more than 10% above baseline on room air
    3. Cyanotic Congenital Heart Disease causes
      1. Supplemental Oxygen 100% increases O2 Sat <85%
      2. Oxygen Saturation drops with Agitation
    4. Also obtain postductal Oxygen Saturation in upper and lower extremities
      1. Note significant discrepancy between upper and lower extremities (4% difference is significant)
      2. Increased discrepancy consistent with Aortic Coarctation, persistent Pulmonary Hypertension
  8. Blood Pressure in all 4 extremities
    1. Pressure gradient >10-20 mmHg between right upper and the lower pressure left leg
      1. May suggest Aortic Coarctation
  9. General Examination
    1. Concurrent Congenital defects (present in 25% of cases)

XI. Labs

  1. Basic metabolic panel (e.g. chem8)
  2. Complete Blood Count (CBC)
  3. Arterial Blood Gas
    1. Drawn from the right radial artery on room air
      1. PaO2 <60 on room air suggests CHD
    2. Consider repeat after 10 minutes on 100% oxygen
      1. PaO2 <150 after 100% oxygen for 10 minutes suggests CHD
      2. Expect PaO2 to increase 30 mmHg or more on oxygen if Cyanosis due to pulmonary cause
      3. Inadequate increase suggests cyanotic heart disease
      4. May also be performed non-invasively with Oxygen Saturation (see signs above)
  4. Labs not routinely recommended
    1. B-Type Natriuretic Peptide
    2. Troponin (non-specific, elevated in Neonatal Respiratory Distress)
  5. Infection evaluation in febrile infants
    1. See Neonatal Sepsis
    2. Blood Culture
    3. Urinalysis
    4. Consider Lumbar Puncture

XII. Imaging

  1. Chest XRay
    1. See Chest XRay in Congenital Heart Disease
    2. Findings may include Cardiomegaly and increased pulmonary vascular markings
  2. Early Echocardiogram
    1. Consider bedside Rapid Ultrasound for Shock and Hypertension (RUSH Exam)
  3. Advanced imaging
    1. Chest MRI

XIII. Diagnostics: Electrocardiogram (EKG)

  1. Normal newborn
    1. Right Axis Deviation (right ventricle dominant)
  2. General abnormalities
    1. Tachycardia
    2. Wide QRS Complex
    3. Non-Sinus Rhythm (no consistent P Waves)
    4. Prolonged QT Interval (especially if >500 ms)
  3. Left Ventricular Hypertrophy
    1. Associated with left-sided obstruction (e.g. Aortic Coarctation, critical Aortic Stenosis)
  4. Right Ventricular Hypertrophy
    1. Associated with right-sided obstruction (e.g. tricuspid or pulmonic atresia, pulmonic stenosis, Pulmonary Hypertension)
    2. Tetralogy of Fallot may demonstrate RVH after 6 months of age
  5. Lext axis deviation (QRS positive in I and negative in II, avF)
    1. Seen in left-to-right shunt, VSD, PDA, tricuspid atresia, Aortic Coarctation
  6. Extreme Right Axis Deviation (QRS negative in I, negative in avF)
    1. Seen in severe pulmonary stenosis, transposition, tetralogy, single ventricle, Truncus Arteriosus, AV canal defect

XIV. Approach: Cardiac Presentations in infants

  1. Nonstructural causes of cardiac emergencies in infants
    1. Arrhythmias (e.g. Bradycardia, Tachycardia)
    2. Myocardial dysfunction
  2. Structural causes of cardiac emergencies in infants
    1. Volume Overload (e.g. VSD, ASD, PDA, TAPVR, Truncus, AV Canal)
    2. Pressure Overload
      1. Left-sided obstruction (e.g. Hypoplastic Left Heart, Aortic Coarctation, Aortic Stenosis or atresia)
      2. Right-sided obstruction (e.g. pulmonary or tricuspid atresia, pulmonic stenosis, Ebstein's Anomaly)

XV. Diagnosis

  1. See Congenital Heart Disease Causes
  2. Early Presentations in Newborns in first month of life (Ductal Dependent Lesions)
    1. Blue Neonate (right-sided obstructive lesion)
      1. Right to left shunt results in systemic Blood Flow (Qs) that is greater than pulmonary Blood Flow (Qp)
      2. Presents with Cyanosis (O2 Sat <65%), but normal perfusion (SBP>70 mmHg)
      3. Causes: Pulmonary or Tricuspid atresia, Tetralogy, Ebstein Anomaly, Transposition
    2. Grey Neonate (left-sided lesion)
      1. Left to right shunt results in pulmonary Blood Flow (Qp) that is greater than systemic Blood Flow (Qs)
      2. Presents in shock with poor perfusion (SBP <60 mmHg), but normal oxygenation (O2 Sat >90%)
      3. Progresses from shock with Tachycardia and vascoconstriction to Left Ventricular Failure and Pulmonary Edema
      4. Causes: Hypoplastic Left Heart, Aortic Coarctation, Aortic Stenosis or atresia
  3. Delayed Presentations in Infants (presenting after first month of life)
    1. Blue Infant (Cyanosis may be subtle)
      1. Mixing of oxygenated and deoxygenated blood AND increased pulmonary Blood Flow (Qp)
      2. Causes: TAPVR, Truncus Arteriosus
    2. Pink Infant (volume overload, Pulmonary Hypertension, CHF)
      1. Left to right shunt results in pulmonary Blood Flow (Qp) that is greater than systemic Blood Flow (Qs)
      2. Causes: ASD, VSD, PDA

XVI. Management: Initial management and stabilization

  1. Pediatric cardiology Consultation (or neonatology if at community hospital)
    1. Obtain early in presentation
  2. Supplemental Oxygen
    1. See precautions regarding hyperoxygenation risks below
    2. Unstable infants should be given initial Supplemental Oxygen regardless of underlying suspected cause
    3. Suspect CHD if clinical status worsens with Supplemental Oxygen or grey, non-cyanotic infant (see above)
      1. Reduce FIO2 to lowest setting that maintains adequate Oxygen Saturation 85-90%
      2. Lower FIO2 allows for greater pulmonary vascular resistance and greater systemic Blood Flow
  3. Intravenous Access
    1. Obtain 2 IVs if PGE-1 use is planned
    2. Umbilical Vein Catheter if unable to place other access
    3. Undifferentiated Shock or following PGE-1 in cyanotic infants may require fluid bolus trial
      1. Normal Saline 5-10 cc/kg bolus may be trialed and then recheck clinical status
  4. Cardiac monitor as well as labs and diagnostics as above
  5. Endotracheal Intubation (if needed, especially after PGE-1)
    1. RSI: Fentanyl 1 mcg/kg and Rocuronium (avoid Benzodiazepines)
    2. Consider Ketamine for sedation in Pulmonary Hypertension (decreases pulmonary vascular resistance)
    3. Consider Atropine for RSI premedication to prevent Bradycardia with intubation
    4. Preoxygenation and Apneic Oxygenation during intubation is still recommended regardless of cardiac defect
    5. Reduce FIO2 grey, non-cyanotic infant to maintain FIO2 85-90% (see above)
  6. Administer Prostaglandin E1 (PGE-1)
    1. Indicated for suspected Ductal Dependent Lesion (most cases with Cyanosis or cardiovascular collapse)
    2. Discuss with Pediatric cardiology, neonatology
    3. Indicated for infant with severe Hypoxia (especially oxygen refractory) or shock
    4. Do not administer without airway and respiratory management equipment at bedside (or intubated)
    5. PGE-1 Low Dose (lower apnea, Hypotension, Bradycardia risks)
      1. Load: 20 ng/kg/min (0.02 mg/kg/min) in 5% Dextrose
      2. Maintenance: 10 ng/kg/min and titrate to effect every 15-20 minutes
    6. PGE-1 High Dose (if patient intubated, refractory to low dose)
      1. Load: 50 ng/kg/min (0.05 mg/kg/min) in 5% Dextrose
      2. Titrated to effect every 15-20 minutes
    7. Monitor clinical status after starting dose
      1. Blood Pressure, perfusion, Capillary Refill and urinary output
      2. Cyanosis and Oxygen Saturation

XVII. Management: Ductal Dependent Lesions

  1. Distinguishing ductal dependent pulmonary versus ductal dependent systemic flow is critical to driving management
    1. Hypotension following PGE-1 is common and should be anticipated
    2. Choosing the wrong agent (i.e. pressor in coarctation) can have lethal consequences
  2. Ductal dependent pulmonary Blood Flow (cyanotic heart disease, blue baby)
    1. Presents with Cyanosis, severely decreased Oxygen Saturation (e.g. 40%) and a normal Chest XRay
    2. Prostaglandin E1 (PGE-1) maintains an open PDA
    3. Hypotension (occurs with PGE-1, requires 2 IV/IO)
      1. Phenylephrine (or Epinephrine, Norepinephrine, Dopamine)
      2. Increases systemic Afterload, shunting blood to the pulmonary circulation
      3. Consider fluid challenge of Normal Saline 5-10 cc/kg
  3. Ductal dependent systemic Blood Flow (acyanotic heart disease, gray baby)
    1. Presents with pink, non-cyanotic with shock, poor perfusion, Hypotension and Tachycardia
    2. Systolic Blood Pressure is significantly higher in arms then legs (in range of 40 mmHg difference)
    3. Chest XRay may show Congestive Heart Failure
    4. Prostaglandin E1 (PGE-1) maintains an open PDA
    5. Treatment goal is Afterload reduction
    6. Hypotension (occurs with PGE-1, requires 2 IV/IO)
      1. Milrinone (preferred)
      2. Dobutamine (second-line alternative)
      3. AVOID Vasopressors (e.g. Phenylephrine, Epinephrine, Norepinephrine)
        1. Risk of worsening an already critical Aortic Coarctation resulting in Cardiac Arrest
  4. References
    1. Sloas, Checchia and Orman in Majoewsky (2013) EM: Rap 13(9): 8

XVIII. Management: Congestive Heart Failure

  1. Obtain Pediatric cardiology Consultation early in presentation
    1. Discuss acute stabilization management as high risk of decompensation
    2. See Complications below
  2. See general measures above
  3. Elevate head of bed 45 degrees
  4. Supplemental Oxygen
    1. Avoid hyperoxygenation (risk of increased Pulmonary Edema)
    2. Adjust FIO2 to achieve Oxygen Saturation >90%
  5. Non-Invasive Positive-pressure ventilation
    1. BiPap is first-line management of CHF
  6. Fluid Overload
    1. Furosemide (Lasix)
    2. Exercise caution with Nitroglycerin (discuss first with cardiology)
      1. Many CHD patients are Preload dependent and may have catastrophic drop in Blood Pressure with nitrates
  7. Hypotension
    1. Inotropes
      1. Milrinone (preferred)
      2. Dobutamine (second-line alternative)
    2. Vasopressors (Norepinephrine, Epinephrine)
      1. Contraindicated in ductal dependent systemic Blood Flow (i.e. Aortic Coarctation) as above

XIX. Precautions: Acute presentation of Congenital Heart Disease

  1. Permissive Hypoxia (85-90% Oxygen Saturation) maintains a Patent Ductus Arteriosus
    1. Allows for compensation prior to definitive management
  2. Avoid hyperoxygenating to 100% Oxygen Saturation in suspected new presentation of Congenital Heart Disease
    1. Risks closure of the ductus arteriosus during the initial evaluation and management
    2. Oxygen Saturation of 85% may be target in these patients (base target on local Consultation)

XX. Prevention: Children with Congenital Heart Disease

  1. Annual Influenza Vaccination
  2. Pneumococcal Vaccination
  3. SBE Prophylaxis

XXI. Prevention: Screening for Congenital Heart Disease in the newborn nursery

  1. Protocol suggested as part of routine well Newborn Exam
    1. Obtain preductal (right arm) and postductal (left leg) before newborn discharge home
  2. Post-ductal Oxygen Saturation is effective screening
    1. Test Sensitivity: 60%
    2. Test Specificity: 99.95%
    3. Koppel (2003) Pediatrics 111:451-5 [PubMed]

XXII. Prognosis

  1. Serious causes of CHD account for 25% of the roughly 40,000 cases in the U.S. per year
  2. Of these serious causes (~10,000 cases/year in U.S.), 25% do not survive beyond first birthday

XXIII. Complications: Post-Cardiac Repair

  1. Background
    1. Congenital Heart surgical repairs include Norwood Procedure, Glenn Procedure, Fontan Procedure, BT Shunt
    2. These repairs have allowed children to survive CHD that would otherwise be fatal
    3. However, the repairs re-route blood to mimic physiologic flow, but these hearts have unique physiology
    4. Homeostasis is an easily disrupted tight balance between Preload dependence and Cardiogenic Shock
    5. Consult Cardiology in all cardiopulmonary presentations and new medications with possible hemodynamic effects
  2. Pulmonary Hypertension
    1. Present in most patients with Congenital Heart Disease who have undergone repair
  3. Chronic Hypoxia (baseline 90-92% Oxygen Saturation)
    1. Hypoxia at baseline is often present after surgical repair
    2. Cardiac repairs often result in venous and arterial admixture by design
  4. Dysrhythmias
    1. Cardiac surgical scars increase risk
  5. Thrombosis risk
    1. Repairs often leave patients with grafts and synthetic shunts that are thrombogenic
  6. References
    1. Shoenberger and Saade in Herbert (2019) EM:Rap 19(12): 2-3

XXIV. Resources

  1. CDC: Congenital Heart Disease Statistics
    1. http://www.cdc.gov/ncbddd/heartdefects/data.html

XXV. References

  1. Civitarese and Crane (2016) Crit Dec Emerg Med 30(1): 14-23
  2. Joseph and Webb (2015) Crit Dec Emerg Med 29(1): 10-8
  3. Cyran (1998) PREP review lecture, October, Phoenix
  4. Fuchs and Yamamoto (2012) APLS, Jones and Bartlett, Burlington, p. 140
  5. Saenz (1999) Am Fam Physician, 59(7):1857-66 [PubMed]
  6. Frank (2011) Am Fam Physician 84(7): 793-800 [PubMed]

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Related Studies

Ontology: Congenital Heart Defects (C0018798)

Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (CHV) Imperfections or malformations of the heart, existing at birth
Definition (MEDLINEPLUS)

A congenital heart defect is a problem with the structure of the heart. It is present at birth. Congenital heart defects are the most common type of birth defect. The defects can involve the walls of the heart, the valves of the heart, and the arteries and veins near the heart. They can disrupt the normal flow of blood through the heart. The blood flow can slow down, go in the wrong direction or to the wrong place, or be blocked completely.

Doctors use a physical exam and special heart tests to diagnose congenital heart defects. They often find severe defects during pregnancy or soon after birth. Signs and symptoms of severe defects in newborns include

  • Rapid breathing
  • Cyanosis - a bluish tint to the skin, lips, and fingernails
  • Fatigue
  • Poor blood circulation

Many congenital heart defects cause few or no signs and symptoms. They are often not diagnosed until children are older.

Many children with congenital heart defects don't need treatment, but others do. Treatment can include medicines, catheter procedures, surgery, and heart transplants. The treatment depends on the type of the defect, how it is, and a child's age, size, and general health.

NIH: National Heart, Lung, and Blood Institute

Definition (MSHCZE) Vrozené vývojové vady postihující srdce (patří k nejčastějším VVV). Kombinace různých anatomických anomálií jednotlivých struktur a přilehlých cév. Vady se dělí podle morfologického defektu nebo funkčně. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (MSH) Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Concepts Congenital Abnormality (T019)
MSH D006330
ICD9 746.9
ICD10 Q24.9
SnomedCT 156911006, 268318000, 204413006, 204405005, 268315002, 156926008, 13213009
English Abnormalities, Heart, Abnormality, Heart, Congenital Heart Defect, Defect, Congenital Heart, Defects, Congenital Heart, Heart Abnormalities, Heart Abnormality, Heart Defect, Congenital, Heart Defects, Congenital, HEART MALFORMATION, Unspecified congenital anomaly of heart, Congenital heart anomaly NOS, Congenital malformation of heart, unspecified, HEART, MALFORMATION OF, Congenital heart defect, Congenital heart defects, HEART DEFECT CONGEN, DEFECTS CONGEN HEART, HEART DEFECTS CONGEN, ABNORM HEART, CONGEN HEART DEFECTS, HEART ABNORM, CONGEN HEART DEFECT, heart defect, congenital heart defect, congenital heart anomaly, congenital heart defect (diagnosis), Anomaly cardiac, Anomaly heart, Heart malformation, Malformation heart (NOS), Congenital cardiac anomalies, Cong heart anomaly NOS, Heart malformations, Heart Defects, Congenital [Disease/Finding], anomaly heart, cardiac abnormality, cardiac anomaly, congenital defects heart, congenital defects hearts, heart malformations, Congenital anomaly;heart, abnormalities cardiac, anomalies cardiac, congenital heart defects, heart anomaly, abnormalities heart, congenital cardiac defect, cardiac congenital defects, anomalies heart, congenital defect heart, heart abnormalities, abnormality cardiac, heart abnormality, heart malformation, Cardiac anomalies, Cardiac abnormalities, Heart, Malformation Of, Heart Defects, Heart-congenital defect, Congenital heart anomaly NOS (disorder), Heart--Abnormalities, Congenital anomaly of heart, cardiac; anomaly, deformity; heart, heart; anomaly, heart; deformity, anomaly; cardiac, anomaly; heart, congenital, anomaly; heart, Congenital anomaly of heart, NOS, Heart Malformation, Congenital anomaly of heart NOS, Congenital Heart Defects, congenital anomaly of the heart
Dutch hartanomalie, hartmisvorming (NAO), niet-gespecificeerde congenitale hartanomalie, hartmisvoming, anomalie; , hart, congenitaal, anomalie; cardiaal, anomalie; hart, cardiaal; anomalie, hart; anomalie, hart; misvorming, misvorming; hart, Congenitale misvorming van hart, niet gespecificeerd, Congenitaal hartdefect, Congenitale misvorming van het hart, Defect, congenitaal hart-, Defecten, congenitale hart-, Hartafwijking, Hartdefect, congenitaal, Hartdefecten, congenitale
French Anomalie cardiaque, Anomalie du coeur, Malformation cardiaque SAI, Anomalie congénitale non précisée du coeur, Anomalie cardiaque congénitale, Anomalies cardiaques congénitales, Malformation cardiaque, Malformations cardiaques, MALFORMATION CARDIAQUE, Cardiopathies congénitales, Cardiopathie congénitale, Anomalie congénitale du coeur, Anomalies congénitales du coeur
German Anomalie, Herz, unspezifische kongenitale Anomalie des Herzens, Herzmissbildung, Missbildung des Herzens NNB, Angeborene Fehlbildung des Herzens, nicht naeher bezeichnet, HERZMISSBILDUNG, Herzfehlbildungen, Herzfehler, kongenitale, Vitium cordis congenitum, Herzfehler, angeborene
Italian Malformazione cardiaca, Anomalia del cuore non specificata, Malformazione cardiaca (NAS), Anomalia cardiaca, Anomalie cardiache, Difetto cardiaco congenito, Difetti cardiaci congeniti
Portuguese Anomalia cardíaca, Anomalia congénita NE do coração, Anomalia do coração, Malformação cardíaca, Malformação cardíaca NE, MALFORMACAO CARDIACA, Defeitos Cardiovasculares Congênitos, Malformação Cardiovascular, Anormalidades Cardíacas, Cardiopatias Congênitas
Spanish Malformación cardiaca, Malformación de corazón (NEOM), Anomalía del corazón, Anomalía cardiaca, Anomalía congénita no especificada del corazón, MALFORMACION CARDIACA, anomalía cardíaca congénita, SAI (trastorno), anomalía cardíaca congénita, SAI, Congenital heart anomaly NOS, Defecto Congénito Cardiovascular, Anomalías Cardíacas Congénitas, anomalía cardíaca congénita, Anomalías Cardíacas, Cardiopatías Congénitas
Japanese 心臓奇形(NOS), 詳細不明の心臓の先天異常, シンゾウキケイNOS, ショウサイフメイノシンゾウノセンテンイジョウ, シンキケイ, 先天性心臓疾患, 先天性心欠損, 心臓奇形, 先天性心疾患, 先天性心臓奇形, 心臓欠損症-先天性, 心臓転位症, 先天性心臓欠損, 心臓奇形-先天性, 先天性心臓欠損症, 先天性心欠損症, 心臓疾患-先天性, 心奇形
Swedish Hjärtfel, medfödda
Czech srdce - vady vrozené, Srdeční malformace, Blíže neurčená vrozená anomálie srdce, Anomálie srdeční, Malformace srdce (NOS), Srdeční anomálie, abnormality srdce, kongenitální srdeční vady, vrozené srdeční vady, srdce - defekty kongenitální, srdeční abnormality, vrozené vady srdce
Finnish Synnynnäiset sydänviat
Korean 상세불명의 심장의 선천 기형
Polish Wady serca wrodzone
Hungarian Szív anomalia, Szívanomalia, Szívmalformatio, Szívmalformatio (k.m.n.), Szív veleszületett nem meghatározott anomaliája
Norwegian Medfødte hjertefeil, Hjertefeil, medfødte, Medfødte misdannelser i hjertet, Vitium cordis congenitum