II. Indications

  1. Limited use in clinical practice
  2. May be indicated if Ankylosing Spondylitis strongly suspected

III. Labs: Methods of Testing

  1. Antibody binding to patient's cells
  2. Mixed Lymphocyte responses against specific targets
  3. Hybridization to DNA probes

V. Causes: Positive HLA-B27 (with Incidence)

  1. Ankylosing Spondylitis: 95%
  2. Reiter's Syndrome (Reactive Arthritis): 80%
  3. Psoriatic Arthritis (Spondylitis with Psoriasis): 70%
  4. Enteropathic Arthritis (Spondylitis with Inflammatory Bowel Disease): 50%
  5. Incidence in general population without disease: 6-8%

VI. References

  1. Gregersen in Ruddy (2001) Kelly's Rheumatology, p. 101
  2. Lane (2002) Am Fam Physician 65(6):1073-80
  3. Ali (2018) Am Fam Physician 98(3): 164-70 [PubMed]

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