II. Mechanism

  1. IgM, IgG, or IgA binding to cell-membrane constituents

III. Screening

  1. Measured by enzyme-linked immunosorbent assay

IV. Types of Antiphospholipid Antibodies

  1. Anticardiolipin (ACL)
  2. Lupus Anticoagulant
    1. Prolongs Partial Thromboplastin Time (PTT)
    2. Prolongs Russell viper venom time
  3. VDRL false positive

V. Condition associated with APL elevations (>3 SD)

VI. Indications fo APL testing

  1. Connective Tissue disease with clotting disorder
  2. Recurrent thrombosis without obvious cause
    1. See Hypercoagulability

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