II. Mechanism
- Vinca alkaloids
- Inhibits mitosis (metaphase arrest)
- Cause disassembly of microtubules
-
Podophyllotoxins
- Block cells in S-G2 phase of cell cycle
- DNA degradation
- Nucleoside transport inhibition
- Mitochondrial electron transport inhibition
III. Medications
- Periwinkle Plant (Vinca rosea) derivative
- Vinblastine (Velban)
- Vincristine (Oncovin)
- Mayapple plant (Podophyllum peltatum) derivative
- Etoposide (VP-16)
- Teniposide (VM-26)