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Free PSAAka: Free Prostate Specific Antigen

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  1. See Also
    1. Prostate Specific Antigen
  2. Mechanism
    1. Free PSA increases more in Benign Prostatic Hypertrophy
    2. PSA associated with cancer is more protein bound
  3. Indication
    1. Detection of Prostate Cancer when PSA 2.5 to 10 ng/ml
  4. Efficacy
    1. Improved Specificity when combined with PSA
  5. Interpretation
    1. Free PSA >27% with lower likelihood of Prostate Cancer
    2. Values suggestive of Prostate Cancer
      1. Total PSA 3.0 to 4.0 with Free PSA <19%
      2. Total PSA 4.0 to 10.0 with Free PSA <17 to 24%
  6. References
    1. Catalona (1995) JAMA :
    2. Gann (2002) J Urol 167:2427
    3. Vashi (1997) Mayo Clin Proc 72:337

Prostate-Specific Antigen (C0138741)

Definition (MSH)A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
Definition (NCI)PSA. A substance produced by the prostate that may be found in an increased amount in the blood of men who have prostate cancer, benign prostatic hyperplasia, or infection or inflammation of the prostate.
Definition (CSP)a tissue kallikrein related sequence enzyme used as a biomarker for prostate cancer or benign prostate hyperplasia.
Definition (NCI)Alternate isoforms of the single-chain 261-aa 30-kD Kallikrein 3 (Prostate Specific Antigen) glycoprotein precursor are encoded by human KLK3 Gene (Kallikrein Family). Frameshifted isoform 2 has a shorter distinct C-terminus. A Kallikrein-like serine protease in seminal plasma, PSA may function in liquefaction of seminal coagulum by (preferential Tyr-X) cleavage of seminal vesicle protein. Kallikrein proteases have diverse functions. Mounting evidence implicates kallikreins in carcinogenesis; some have potential as cancer biomarkers. The serum level of PSA is useful in diagnosis and monitoring of prostatic carcinoma, benign prostate hyperplasia, or infection or inflammation of the prostate. (NCI)
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126) , Immunologic Factor (T129)
MSHD017430
EnglishEC 3.4.21.34, Fletcher Factor, gamma Seminoprotein, Gamma-Seminoprotein, HK 003 KALLIKREIN, hK3 Kallikrein, Kallikrein 3, KALLIKREIN HK 003, Kallikrein hK3, Kininogenin, KLK3, P-30 antigen, Plasma Kallikrein Precursor, Plasma Prekallikrein, Prostate specific Ag, Prostate specific antigen, Prostate Specific Antigen Preproprotein, Prostate-Specific Antigen, PSA, PSA - Prostate specific antigen, Semenogelase, Seminin
Spanishantigeno P - 30, antigeno prostatico especifico, semenogelasa, seminina
Parent ConceptsKininogenase (C0022478), Antigens, Neoplasm (C0003335), Tumor Markers, Biological (C0041366), Prostatic Secretory Proteins (C0969723), Hydrolase (C0020289), Proteins (C0033684), Peptide Hydrolases (C0030940), Duplicate concept (C1274013)
SourcesCSP, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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