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Bile Acid Oral Dissolution Therapy

Aka: Bile Acid Oral Dissolution Therapy, Ursodeoxycholic Acid, Ursodiol, Actigal, Oral Dissolution Therapy
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  1. Indication: Cholelithiasis
    1. Comorbid condition that precludes safe Cholecystectomy
    2. Symptomatic patient unwilling to undergo surgery
  2. Inclusion Criteria required (only 15% of patients)
    1. Small, floating, CholesterolGallstones (<0.5mm)
    2. Functional Gallbladder
  3. Treatment Protocol: Ursodiol (Actigal)
    1. Dose: 8-10 mg/kg/day PO divided bid to tid
    2. Course: 6-12 months
  4. Efficacy
    1. Stones dissolving over 6-12 months: 60-90%
    2. Stones reoccuring within 5 years: 25-50%
    3. Better prognosis associated factors
      1. Single Gallstone and
      2. non-obese and
      3. Young patient
Medication Costs
Ursodiol (on 2/9/2012 at DrugStore.com)
Ursodiol 250mg Tablets #100 for $213.99 ($2.14/unit)
Ursodiol 500mg Tablets #100 for $404.99 ($4.05/unit)
Ursodiol 300mg Capsules #30 for $71.99 ($2.40/unit)
Actigall (on 2/9/2012 at DrugStore.com)
Actigall 300mg Capsules #30 for $198.98 ($6.63/unit)
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ursodiol (C0042105)

Definition (NCI) A drug that is used to dissolve gallstones in people who can't have surgery to remove them. It is also being studied in the prevention of colorectal cancer. Ursodiol belongs to the family of drugs called anticholelithics.
Definition (MSH) An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Definition (NCI) A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract.
Definition (PDQ) A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=306453&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=306453&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1818" NCI Thesaurus)
Concepts Steroid (T110) , Pharmacologic Substance (T121) , Biologically Active Substance (T123)
MSH D014580
SnomedCT 386889007, 41143004, 108669000, 317791009
English Acid, Deoxyursocholic, Acid, Ursacholic, Acid, Ursodeoxycholic, Deoxyursocholic Acid, Ursacholic Acid, Ursodeoxycholic Acid, 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid, Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7beta)-, (3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid, Ursodiol, URSODIOL, ursodiol, Ursodiol (substance), Ursodeoxycholic acid (substance), ursodiol (medication), gall stone dissolution ursodiol, Ursodeoxycholic Acid [Chemical/Ingredient], 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid, Ursodeoxycholic acid, 3 alpha, 7 beta Dihydroxy-5 beta cholanic acid, UDCA - Ursodeoxycholic acid, Ursodesoxycholic acid, Ursodiol (product), ursodeoxycholic acid, UDCA, Ursodeoxycholic acid [dup] (substance), Ursodeoxycholic acid product
Swedish Ursodeoxycholsyra
Spanish ácido urodesoxicólico, Ursodeoxycholic acid [dup] (substance), Ursodiol, Ursodesoxycholic acid, Ursodeoxycholic acid, UDCA - Ursodeoxycholic acid, Ursodeoxycholic acid product, ursodiol (sustancia), ácido ursodesoxicólico, ácido ursodesoxicólico (sustancia), ursodiol (producto), ursodiol, ácido colánico 3 alfa, 7 beta dihidroxi - 5 beta, ácido urodesoxicólico (sustancia), ácido 3 alfa, 7 beta dihidroxi - 5 beta-colánico, Acido Desoxiursocolico, Acido Ursodesoxicolico, Ácido Desoxiursocólico, Ácido Ursodesoxicólico
Czech kyselina ursodeoxycholová
Finnish Ursodeoksikoolihappo
Russian DEZOKSIURSOKHOLEVAIA KISLOTA, URSODEZOKSIKHOLEVAIA KISLOTA, URSOFAL'K, ДЕЗОКСИУРСОХОЛЕВАЯ КИСЛОТА, УРСОДЕЗОКСИХОЛЕВАЯ КИСЛОТА, УРСОФАЛЬК
Japanese ウルソデスオキシコール酸, 3α,7β-ジヒドロキシ-5β-コラン-24-酸, デオキシウルソコール酸, ウルソデオキシコール酸
Polish Kwas ursodeoksycholowy
French Acide ursodésoxycholique, Ursodésoxycholique, acide
German Desoxyursocholsäure, Ursodesoxycholsäure
Italian Acido ursodesossicolico
Portuguese Ácido Desoxiursocólico, Ácido Ursodesoxicólico
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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