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Antiphospholipid AntibodyAka: aPL Antibody, Antiphospholipid Antibodies

See Also
1. Antinuclear Antibody
Mechanism
1. IgM, IgG, or IgA binding to cell-membrane constituents
Screening
1. Measured by enzyme-linked immunosorbent assay
Types of Antiphospholipid Antibodies
1. Anticardiolipin (ACL)
2. Lupus Anticoagulant
  1. Prolongs Partial Thromboplastin Time (PTT)
  2. Prolongs Russell viper venom time
3. VDRL false positive
Condition associated with APL elevations (>3 SD)
1. Antiphospholipid Antibody Syndrome
Indications fo APL testing
1. Connective Tissue disease with clotting disorder
2. Recurrent thrombosis without obvious cause
  1. See Hypercoagulability

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 2/26/2010. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.