ANA Staining Pattern

Aka: ANA Staining Pattern, ANA Rim Pattern, ANA Peripheral Pattern, ANA Homogenous Pattern, ANA Speckled Pattern, ANA Nucleolar Pattern, ANA Diffuse Pattern, ANA Centromere Pattern, Serum ANA pattern, IgG Nuclear Staining Pattern, Nuclear Antibody Pattern Determination

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II. Causes: Rim Pattern (Peripheral Pattern)

  1. Systemic Lupus Erythematosus (Most Specific)

III. Causes: Homogenous Pattern (Diffuse Pattern)

  1. Systemic Lupus Erythematosus (Very specific)
  2. Further evaluation
    1. Anti-dsDNA
    2. Anti-ssDNA
    3. Anti-Smith

IV. Causes: Speckled Pattern

  1. Most common, least specific
  2. Disorders
    1. Systemic Lupus Erythematosus
    2. Mixed Connective Tissue Disease
    3. Scleroderma
    4. Sjogren's Syndrome
  3. Further evaluation
    1. Smith Antibody (Anti-Smith)
    2. Ribonucleoprotein Antibody (Anti-RNP)
    3. Scl-70 kD kinetochore (Anti-Topoisomerase I)
    4. Anti-La (Anti-SSB)

V. Causes: Nucleolar Pattern

  1. Disorders
    1. Scleroderma
    2. CREST syndrome
  2. Further evaluation
    1. Scl-70 kD kinetochore (Anti-Topoisomerase I)
    2. PM-1

VI. Causes: Centromere Pattern

  1. Seen in PSS with CREST syndrome

VII. References

  1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
  2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
  3. Callegari (1995) Postgrad Med, 97(4):65-74 [PubMed]
  4. Lane (2002) Am Fam Physician 65(6):1073-80 [PubMed]

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