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Cation-Exchange resin
Aka: Cation-Exchange resin, Kayexalate, Sodium Polystyrene Sulfonate
- Indications
- Symptomatic Hyperkalemia
- Mechanism
- Each gram of Kayexalate binds 1 meq/L Potassium
- Precautions
- Risk or Fluid Overload
- Contraindications
- Congestive Heart Failure
- Severe Hypertension
- Dosing
- Oral
- Kayexalate 15-30 g PO in 50-100 ml of 20% Sorbitol
- May be repeated every 3-4 hours up to 4-5 doses/day
- Retention Enema
- Kayexalate 30-60 grams
- Dissolve in 200 ml of 20% Sorbitol or 20% D5W
- Retained for 30-60 min (use inflated rectal catheter)
- May repeat every 6 hours up to 4 doses per day